DEM modeling of high shear wet granulation of a simple system

High shear wet granulation (HSWG) is one of the most poorly understood processes with known difficulties in optimization and scale up. The purpose of the current study is to develop a DEM model which can be applied under dynamic process conditions with high predictive capacity to improve process ins...

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Main Authors: Saurabh Sarkar, Bodhisattwa Chaudhuri
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Asian Journal of Pharmaceutical Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087617300685
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spelling doaj-9b826eb0f98c4cd8b8c1bfb2b0d2be6c2020-11-24T21:24:41ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762018-05-01133220228DEM modeling of high shear wet granulation of a simple systemSaurabh Sarkar0Bodhisattwa Chaudhuri1Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USADepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA; Institute of Material Sciences, University of Connecticut, Storrs, CT 06269, USA; Corresponding author. University of Connecticut, 69 N Eagleville Rd, School of Pharmacy, Rm 502, Storrs, CT 06269, USA. Tel.: +1 860 4864861.High shear wet granulation (HSWG) is one of the most poorly understood processes with known difficulties in optimization and scale up. The purpose of the current study is to develop a DEM model which can be applied under dynamic process conditions with high predictive capacity to improve process insight. The DEM model is used to predict agglomeration as a function of impeller speed and liquid addition rate in a high shear wet granulator. The DEM model tracks dynamic formation and breakage of liquid bridges between particles as liquid binder in the system is added, and corrects for the change in material properties as a function of the binder content. Keywords: High shear wet granulation, Discrete element method, Capillary bridge modelhttp://www.sciencedirect.com/science/article/pii/S1818087617300685
collection DOAJ
language English
format Article
sources DOAJ
author Saurabh Sarkar
Bodhisattwa Chaudhuri
spellingShingle Saurabh Sarkar
Bodhisattwa Chaudhuri
DEM modeling of high shear wet granulation of a simple system
Asian Journal of Pharmaceutical Sciences
author_facet Saurabh Sarkar
Bodhisattwa Chaudhuri
author_sort Saurabh Sarkar
title DEM modeling of high shear wet granulation of a simple system
title_short DEM modeling of high shear wet granulation of a simple system
title_full DEM modeling of high shear wet granulation of a simple system
title_fullStr DEM modeling of high shear wet granulation of a simple system
title_full_unstemmed DEM modeling of high shear wet granulation of a simple system
title_sort dem modeling of high shear wet granulation of a simple system
publisher Elsevier
series Asian Journal of Pharmaceutical Sciences
issn 1818-0876
publishDate 2018-05-01
description High shear wet granulation (HSWG) is one of the most poorly understood processes with known difficulties in optimization and scale up. The purpose of the current study is to develop a DEM model which can be applied under dynamic process conditions with high predictive capacity to improve process insight. The DEM model is used to predict agglomeration as a function of impeller speed and liquid addition rate in a high shear wet granulator. The DEM model tracks dynamic formation and breakage of liquid bridges between particles as liquid binder in the system is added, and corrects for the change in material properties as a function of the binder content. Keywords: High shear wet granulation, Discrete element method, Capillary bridge model
url http://www.sciencedirect.com/science/article/pii/S1818087617300685
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AT bodhisattwachaudhuri demmodelingofhighshearwetgranulationofasimplesystem
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