DEM modeling of high shear wet granulation of a simple system
High shear wet granulation (HSWG) is one of the most poorly understood processes with known difficulties in optimization and scale up. The purpose of the current study is to develop a DEM model which can be applied under dynamic process conditions with high predictive capacity to improve process ins...
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Elsevier
2018-05-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087617300685 |
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doaj-9b826eb0f98c4cd8b8c1bfb2b0d2be6c2020-11-24T21:24:41ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762018-05-01133220228DEM modeling of high shear wet granulation of a simple systemSaurabh Sarkar0Bodhisattwa Chaudhuri1Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USADepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA; Institute of Material Sciences, University of Connecticut, Storrs, CT 06269, USA; Corresponding author. University of Connecticut, 69 N Eagleville Rd, School of Pharmacy, Rm 502, Storrs, CT 06269, USA. Tel.: +1 860 4864861.High shear wet granulation (HSWG) is one of the most poorly understood processes with known difficulties in optimization and scale up. The purpose of the current study is to develop a DEM model which can be applied under dynamic process conditions with high predictive capacity to improve process insight. The DEM model is used to predict agglomeration as a function of impeller speed and liquid addition rate in a high shear wet granulator. The DEM model tracks dynamic formation and breakage of liquid bridges between particles as liquid binder in the system is added, and corrects for the change in material properties as a function of the binder content. Keywords: High shear wet granulation, Discrete element method, Capillary bridge modelhttp://www.sciencedirect.com/science/article/pii/S1818087617300685 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Saurabh Sarkar Bodhisattwa Chaudhuri |
| spellingShingle |
Saurabh Sarkar Bodhisattwa Chaudhuri DEM modeling of high shear wet granulation of a simple system Asian Journal of Pharmaceutical Sciences |
| author_facet |
Saurabh Sarkar Bodhisattwa Chaudhuri |
| author_sort |
Saurabh Sarkar |
| title |
DEM modeling of high shear wet granulation of a simple system |
| title_short |
DEM modeling of high shear wet granulation of a simple system |
| title_full |
DEM modeling of high shear wet granulation of a simple system |
| title_fullStr |
DEM modeling of high shear wet granulation of a simple system |
| title_full_unstemmed |
DEM modeling of high shear wet granulation of a simple system |
| title_sort |
dem modeling of high shear wet granulation of a simple system |
| publisher |
Elsevier |
| series |
Asian Journal of Pharmaceutical Sciences |
| issn |
1818-0876 |
| publishDate |
2018-05-01 |
| description |
High shear wet granulation (HSWG) is one of the most poorly understood processes with known difficulties in optimization and scale up. The purpose of the current study is to develop a DEM model which can be applied under dynamic process conditions with high predictive capacity to improve process insight. The DEM model is used to predict agglomeration as a function of impeller speed and liquid addition rate in a high shear wet granulator. The DEM model tracks dynamic formation and breakage of liquid bridges between particles as liquid binder in the system is added, and corrects for the change in material properties as a function of the binder content. Keywords: High shear wet granulation, Discrete element method, Capillary bridge model |
| url |
http://www.sciencedirect.com/science/article/pii/S1818087617300685 |
| work_keys_str_mv |
AT saurabhsarkar demmodelingofhighshearwetgranulationofasimplesystem AT bodhisattwachaudhuri demmodelingofhighshearwetgranulationofasimplesystem |
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