Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

Disruption of the dynamic properties of mitochondria (fission, fusion, transport, degradation, and biogenesis) has been implicated in the pathogenesis of neurodegenerative disorders, including Parkinson's disease (PD). Parkin, the product of gene PARK2 whose mutation causes familial PD, has bee...

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Bibliographic Details
Main Authors: Victor S. Van Laar, Nikita Roy, Annie Liu, Swati Rajprohat, Beth Arnold, April A. Dukes, Cory D. Holbein, Sarah B. Berman
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Parkin
Mitochondria
Mitophagy
Endoplasmic reticulum
Glutamate
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003611

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http://www.sciencedirect.com/science/article/pii/S0969996114003611

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