Effect of dexmedetomidine on cerebral oxygen metabolism, nerve function and inflammation in patients with carotid endarterectomy

• Main Author: Jing Liu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-06-01
• Series: Journal of Hainan Medical University
• Subjects: Carotid endarterectomy; Dexmedetomidine; Cerebral oxygen metabolism; Nerve function
• Online Access: http://www.hnykdxxb.com/PDF/201611/17.pdf

Objective: To analyze the regulating effect of dexmedetomidine on cerebral oxygen metabolism, nerve function and inflammation in patients with carotid endarterectomy. Methods: A total of 62 patients receiving carotid endarterectomy in our hospital from August 2012 to January 2015 were included for study and randomly divided into observation group and control group by half. Control group received conventional anesthesia, observation group received dexmedetomidine during operation, and then differences in levels of intraoperative cerebrovascular hemodynamic indicators, cerebral oxygen metabolism indicators, nerve function-related indicators, inflammation-related indicators and so on were compared between two groups. Results: Early postoperative Vmean and Qmean values of observation group were higher than those of control group, and Wv, R and DP values were lower than those of control group (P<0.05); CjvO2, COER and SjvO2 values were higher than those of control group, and Da-jvO2 value was lower than that of control group (P<0.05); intraoperative serum ICAM-1, IL-13, TGF-β, IL-17A, ET and NF-kB values of observation group were lower than those of control group (P<0.05). Conclusions: Intraoperative application of dexmedetomidine for patients with carotid endarterectomy can effectively protect the brain and reduce cerebral oxygen metabolism and systemic inflammation, and it has active clinical significance.