Albumin-Binding and Tumor Vasculature Determine the Antitumor Effect of 15-Deoxy-Δ12,14-Prostaglandin-J2in vivo

15-Deoxy-Δ12,14-prostaglandin-J2 (15d-PGJ2), a peroxisome proliferator-activated receptor γ (PPARγ) agonist, induces cell death in tumor cells in vitro; however, no study showed its in vivo effect on tumors. Here, we report that 15d-PGJ2 shows antitumor effects in vivo in mice. However, its effects...

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Bibliographic Details
Main Authors: Jai Prakash, Ruchi Bansal, Eduard Post, Alie de Jager-Krikken, Marjolijn N. Lub-de Hooge, Klaas Poelstra
Format: Article
Language:English
Published: Elsevier 2009-12-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558609801048

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