Albumin-Binding and Tumor Vasculature Determine the Antitumor Effect of 15-Deoxy-Δ12,14-Prostaglandin-J2in vivo
15-Deoxy-Δ12,14-prostaglandin-J2 (15d-PGJ2), a peroxisome proliferator-activated receptor γ (PPARγ) agonist, induces cell death in tumor cells in vitro; however, no study showed its in vivo effect on tumors. Here, we report that 15d-PGJ2 shows antitumor effects in vivo in mice. However, its effects...
Main Authors: | Jai Prakash, Ruchi Bansal, Eduard Post, Alie de Jager-Krikken, Marjolijn N. Lub-de Hooge, Klaas Poelstra |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2009-12-01
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Series: | Neoplasia: An International Journal for Oncology Research |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558609801048 |
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