Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction
Reliable EEG source analysis depends on sufficiently detailed and accurate head models. In this study, we investigate how uncertainties inherent to the experimentally determined conductivity values of the different conductive compartments influence the results of EEG source analysis. In a single sou...
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doaj-9baf3cd583a3413bbc68291bc5c9b3db2020-11-25T01:39:51ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-06-011310.3389/fnins.2019.00531448691Influence of Head Tissue Conductivity Uncertainties on EEG Dipole ReconstructionJohannes Vorwerk0Johannes Vorwerk1Johannes Vorwerk2Ümit Aydin3Ümit Aydin4Carsten H. Wolters5Carsten H. Wolters6Christopher R. Butson7Christopher R. Butson8Christopher R. Butson9Scientific Computing & Imaging (SCI) Institute, University of Utah, Salt Lake City, UT, United StatesInstitute for Biomagnetism and Biosignalanalysis, University of Münster, Münster, GermanyInstitute of Electrical and Biomedical Engineering, UMIT - University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, AustriaInstitute for Biomagnetism and Biosignalanalysis, University of Münster, Münster, GermanyMultimodal Functional Imaging Lab, Department of Physics and PERFORM Centre, Concordia University, Montreal, QC, CanadaInstitute for Biomagnetism and Biosignalanalysis, University of Münster, Münster, GermanyOtto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster, GermanyScientific Computing & Imaging (SCI) Institute, University of Utah, Salt Lake City, UT, United StatesDepartments of Biomedical Engineering, Neurology, and Psychiatry, University of Utah, Salt Lake City, UT, United StatesDepartment of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, United StatesReliable EEG source analysis depends on sufficiently detailed and accurate head models. In this study, we investigate how uncertainties inherent to the experimentally determined conductivity values of the different conductive compartments influence the results of EEG source analysis. In a single source scenario, the superficial and focal somatosensory P20/N20 component, we analyze the influence of varying conductivities on dipole reconstructions using a generalized polynomial chaos (gPC) approach. We find that in particular the conductivity uncertainties for skin and skull have a significant influence on the EEG inverse solution, leading to variations in source localization by several centimeters. The conductivity uncertainties for gray and white matter were found to have little influence on the source localization, but a strong influence on the strength and orientation of the reconstructed source, respectively. As the CSF conductivity is most accurately determined of all conductivities in a realistic head model, CSF conductivity uncertainties had a negligible influence on the source reconstruction. This small uncertainty is a further benefit of distinguishing the CSF in realistic volume conductor models.https://www.frontiersin.org/article/10.3389/fnins.2019.00531/fullEEG source analysisEEG dipole reconstructionhead modelingsensitivity analysisconductivity uncertaintyconductivity estimation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Johannes Vorwerk Johannes Vorwerk Johannes Vorwerk Ümit Aydin Ümit Aydin Carsten H. Wolters Carsten H. Wolters Christopher R. Butson Christopher R. Butson Christopher R. Butson |
spellingShingle |
Johannes Vorwerk Johannes Vorwerk Johannes Vorwerk Ümit Aydin Ümit Aydin Carsten H. Wolters Carsten H. Wolters Christopher R. Butson Christopher R. Butson Christopher R. Butson Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction Frontiers in Neuroscience EEG source analysis EEG dipole reconstruction head modeling sensitivity analysis conductivity uncertainty conductivity estimation |
author_facet |
Johannes Vorwerk Johannes Vorwerk Johannes Vorwerk Ümit Aydin Ümit Aydin Carsten H. Wolters Carsten H. Wolters Christopher R. Butson Christopher R. Butson Christopher R. Butson |
author_sort |
Johannes Vorwerk |
title |
Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction |
title_short |
Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction |
title_full |
Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction |
title_fullStr |
Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction |
title_full_unstemmed |
Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction |
title_sort |
influence of head tissue conductivity uncertainties on eeg dipole reconstruction |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2019-06-01 |
description |
Reliable EEG source analysis depends on sufficiently detailed and accurate head models. In this study, we investigate how uncertainties inherent to the experimentally determined conductivity values of the different conductive compartments influence the results of EEG source analysis. In a single source scenario, the superficial and focal somatosensory P20/N20 component, we analyze the influence of varying conductivities on dipole reconstructions using a generalized polynomial chaos (gPC) approach. We find that in particular the conductivity uncertainties for skin and skull have a significant influence on the EEG inverse solution, leading to variations in source localization by several centimeters. The conductivity uncertainties for gray and white matter were found to have little influence on the source localization, but a strong influence on the strength and orientation of the reconstructed source, respectively. As the CSF conductivity is most accurately determined of all conductivities in a realistic head model, CSF conductivity uncertainties had a negligible influence on the source reconstruction. This small uncertainty is a further benefit of distinguishing the CSF in realistic volume conductor models. |
topic |
EEG source analysis EEG dipole reconstruction head modeling sensitivity analysis conductivity uncertainty conductivity estimation |
url |
https://www.frontiersin.org/article/10.3389/fnins.2019.00531/full |
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