The physical sequelae of perinatally acquired HIV in adolescents: a research proposal

• Main Authors: Nicolette Comley-White, Joanne Potterton, Veronica Ntsiea
• Format: Article
• Language: English
• Published: BMC 2019-01-01
• Series: BMC Research Notes
• Subjects: HIV; Perinatally infected; Adolescents; Physical
• Online Access: http://link.springer.com/article/10.1186/s13104-019-4079-5

Abstract Objectives As the global access of antiretrovirals for HIV-infected infants improves, so the body of perinatally HIV-infected adolescents (PHIVA) grows. The neurological and physical complications of HIV, both in children and in adults, are well established, however there is a paucity of data pertaining to PHIVA, a group of people who have had a lifetime exposure to the virus and to antiretrovirals. There has been a resounding call for further research in this area, as well as for the development of policies and programmes for this population. The aim of this study is to determine the physical sequelae in PHIVA and to propose a model of care for this population. Methods Through interviews with PHIVA, the perceived physical challenges will be established. Thereafter a cohort study with age-matched participants will determine if PHIVA have any limitations in fatigue, endurance, motor function and muscle strength, body mass index, peripheral neuropathy, level of disability and quality of life. Using these results, a model of care will be proposed through the nominal group technique with both PHIVA and clinicians working in HIV and adolescence.