Locomotion guidance by extracellular matrix is adaptive and can be restored by a transient change in Ca2+ level.

Navigation of cell locomotion by gradients of soluble factors can be desensitized if the concentration of the chemo-attractant stays unchanged. It remains obscure if the guidance by immobilized extracellular matrix (ECM) as the substrate is also adaptive and if so, how can the desensitized ECM guida...

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Bibliographic Details
Main Authors: Hong-Wen Liu, Yun-Cin Luo, Chia-Lin Ho, Jung-Yen Yang, Chi-Hung Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2752192?pdf=render