NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis
Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA...
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doaj-9bbf5c8ccdd6410ab0a9476f3609dc2a2020-11-24T21:23:42ZengMDPI AGInternational Journal of Molecular Sciences1422-00672013-08-01148171111712110.3390/ijms140817111NF90 in Posttranscriptional Gene Regulation and MicroRNA BiogenesisIssei ImotoKazuhito RokutanKensei NishidaKiyoshi MasudaYuki KuwanoGene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA binding proteins (DSRBPs) are known to regulate many processes of cellular metabolism, including transcriptional control, translational control, mRNA processing and localization. Nuclear factor 90 (NF90), one of the DSRBPs, is abundantly expressed in vertebrate tissue and participates in many aspects of RNA metabolism. NF90 was originally purified as a component of a DNA binding complex which binds to the antigen recognition response element 2 in the interleukin 2 promoter. Recent studies have provided us with interesting insights into its possible physiological roles in RNA metabolism, including transcription, degradation, and translation. In addition, it was shown that NF90 regulates microRNA expression. In this review, we try to focus on the function of NF90 in posttranscriptional gene regulation and microRNA biogenesis.http://www.mdpi.com/1422-0067/14/8/17111NF90double-stranded RNA binding proteinsposttranscriptional regulationmicroRNA biogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Issei Imoto Kazuhito Rokutan Kensei Nishida Kiyoshi Masuda Yuki Kuwano |
spellingShingle |
Issei Imoto Kazuhito Rokutan Kensei Nishida Kiyoshi Masuda Yuki Kuwano NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis International Journal of Molecular Sciences NF90 double-stranded RNA binding proteins posttranscriptional regulation microRNA biogenesis |
author_facet |
Issei Imoto Kazuhito Rokutan Kensei Nishida Kiyoshi Masuda Yuki Kuwano |
author_sort |
Issei Imoto |
title |
NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis |
title_short |
NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis |
title_full |
NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis |
title_fullStr |
NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis |
title_full_unstemmed |
NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis |
title_sort |
nf90 in posttranscriptional gene regulation and microrna biogenesis |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2013-08-01 |
description |
Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA binding proteins (DSRBPs) are known to regulate many processes of cellular metabolism, including transcriptional control, translational control, mRNA processing and localization. Nuclear factor 90 (NF90), one of the DSRBPs, is abundantly expressed in vertebrate tissue and participates in many aspects of RNA metabolism. NF90 was originally purified as a component of a DNA binding complex which binds to the antigen recognition response element 2 in the interleukin 2 promoter. Recent studies have provided us with interesting insights into its possible physiological roles in RNA metabolism, including transcription, degradation, and translation. In addition, it was shown that NF90 regulates microRNA expression. In this review, we try to focus on the function of NF90 in posttranscriptional gene regulation and microRNA biogenesis. |
topic |
NF90 double-stranded RNA binding proteins posttranscriptional regulation microRNA biogenesis |
url |
http://www.mdpi.com/1422-0067/14/8/17111 |
work_keys_str_mv |
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1725991576294916096 |