Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum.
Transitions between different behavioral states, such as sleep or wakefulness, quiescence or attentiveness, occur in part through transitions from action potential bursting to single spiking. Cortical activity, for example, is determined in large part by the spike output mode from the thalamus, whic...
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2005-06-01
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Online Access: | https://doi.org/10.1371/journal.pbio.0030175 |
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doaj-9bc190e3b1214a31b1ed4aedbf4c27b92021-07-02T17:20:02ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852005-06-0136e17510.1371/journal.pbio.0030175Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum.Donald C CooperSungkwon ChungNelson SprustonTransitions between different behavioral states, such as sleep or wakefulness, quiescence or attentiveness, occur in part through transitions from action potential bursting to single spiking. Cortical activity, for example, is determined in large part by the spike output mode from the thalamus, which is controlled by the gating of low-voltage-activated calcium channels. In the subiculum--the major output of the hippocampus--transitions occur from bursting in the delta-frequency band to single spiking in the theta-frequency band. We show here that these transitions are influenced strongly by the inactivation kinetics of voltage-gated sodium channels. Prolonged inactivation of sodium channels is responsible for an activity-dependent switch from bursting to single spiking, constituting a novel mechanism through which network dynamics are controlled by ion channel gating.https://doi.org/10.1371/journal.pbio.0030175 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Donald C Cooper Sungkwon Chung Nelson Spruston |
spellingShingle |
Donald C Cooper Sungkwon Chung Nelson Spruston Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. PLoS Biology |
author_facet |
Donald C Cooper Sungkwon Chung Nelson Spruston |
author_sort |
Donald C Cooper |
title |
Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. |
title_short |
Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. |
title_full |
Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. |
title_fullStr |
Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. |
title_full_unstemmed |
Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. |
title_sort |
output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Biology |
issn |
1544-9173 1545-7885 |
publishDate |
2005-06-01 |
description |
Transitions between different behavioral states, such as sleep or wakefulness, quiescence or attentiveness, occur in part through transitions from action potential bursting to single spiking. Cortical activity, for example, is determined in large part by the spike output mode from the thalamus, which is controlled by the gating of low-voltage-activated calcium channels. In the subiculum--the major output of the hippocampus--transitions occur from bursting in the delta-frequency band to single spiking in the theta-frequency band. We show here that these transitions are influenced strongly by the inactivation kinetics of voltage-gated sodium channels. Prolonged inactivation of sodium channels is responsible for an activity-dependent switch from bursting to single spiking, constituting a novel mechanism through which network dynamics are controlled by ion channel gating. |
url |
https://doi.org/10.1371/journal.pbio.0030175 |
work_keys_str_mv |
AT donaldccooper outputmodetransitionsarecontrolledbyprolongedinactivationofsodiumchannelsinpyramidalneuronsofsubiculum AT sungkwonchung outputmodetransitionsarecontrolledbyprolongedinactivationofsodiumchannelsinpyramidalneuronsofsubiculum AT nelsonspruston outputmodetransitionsarecontrolledbyprolongedinactivationofsodiumchannelsinpyramidalneuronsofsubiculum |
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1721325647697018880 |