Preferentially Expressed Antigen of Melanoma Prevents Lung Cancer Metastasis.
Lung cancer is the most common cause of cancer death worldwide. The poor survival rate is largely due to the extensive local invasion and metastasis. However, the mechanisms underlying the invasion and metastasis of lung cancer cells remain largely elusive. In this study, we examined the role of pre...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4938541?pdf=render |
id |
doaj-9bc8219b81104a63b097788adc3ea6d5 |
---|---|
record_format |
Article |
spelling |
doaj-9bc8219b81104a63b097788adc3ea6d52020-11-25T00:02:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01117e014964010.1371/journal.pone.0149640Preferentially Expressed Antigen of Melanoma Prevents Lung Cancer Metastasis.Quan HuangHaifeng WeiZhipeng WuLin LiLiangfang YaoZhengwang SunLei LiZaijun LinWei XuShuai HanWenjiao CaoYunfei XuDianwen SongXinghai YangJianru XiaoLung cancer is the most common cause of cancer death worldwide. The poor survival rate is largely due to the extensive local invasion and metastasis. However, the mechanisms underlying the invasion and metastasis of lung cancer cells remain largely elusive. In this study, we examined the role of preferentially expressed antigen of melanoma (PRAME) in lung cancer metastasis. Our results show that PRAME is downregulated in lung adenocarcinoma and lung bone metastasis compared with normal human lung. Knockdown of PRAME decreases the expression of E-Cadherin and promotes the proliferation, invasion, and metastasis of lung cancer cells by regulating multiple critical genes, most of which are related to cell migration, including MMP1, CCL2, CTGF, and PLAU. Clinical data analysis reveals that the expression of MMP1 correlates with the clinical features and outcome of lung adenocarcinoma. Taken together, our data demonstrate that PRAME plays a role in preventing the invasion and metastasis of lung adenocarcinoma and novel diagnostic or therapeutic strategies can be developed by targeting PRAME.http://europepmc.org/articles/PMC4938541?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Quan Huang Haifeng Wei Zhipeng Wu Lin Li Liangfang Yao Zhengwang Sun Lei Li Zaijun Lin Wei Xu Shuai Han Wenjiao Cao Yunfei Xu Dianwen Song Xinghai Yang Jianru Xiao |
spellingShingle |
Quan Huang Haifeng Wei Zhipeng Wu Lin Li Liangfang Yao Zhengwang Sun Lei Li Zaijun Lin Wei Xu Shuai Han Wenjiao Cao Yunfei Xu Dianwen Song Xinghai Yang Jianru Xiao Preferentially Expressed Antigen of Melanoma Prevents Lung Cancer Metastasis. PLoS ONE |
author_facet |
Quan Huang Haifeng Wei Zhipeng Wu Lin Li Liangfang Yao Zhengwang Sun Lei Li Zaijun Lin Wei Xu Shuai Han Wenjiao Cao Yunfei Xu Dianwen Song Xinghai Yang Jianru Xiao |
author_sort |
Quan Huang |
title |
Preferentially Expressed Antigen of Melanoma Prevents Lung Cancer Metastasis. |
title_short |
Preferentially Expressed Antigen of Melanoma Prevents Lung Cancer Metastasis. |
title_full |
Preferentially Expressed Antigen of Melanoma Prevents Lung Cancer Metastasis. |
title_fullStr |
Preferentially Expressed Antigen of Melanoma Prevents Lung Cancer Metastasis. |
title_full_unstemmed |
Preferentially Expressed Antigen of Melanoma Prevents Lung Cancer Metastasis. |
title_sort |
preferentially expressed antigen of melanoma prevents lung cancer metastasis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
Lung cancer is the most common cause of cancer death worldwide. The poor survival rate is largely due to the extensive local invasion and metastasis. However, the mechanisms underlying the invasion and metastasis of lung cancer cells remain largely elusive. In this study, we examined the role of preferentially expressed antigen of melanoma (PRAME) in lung cancer metastasis. Our results show that PRAME is downregulated in lung adenocarcinoma and lung bone metastasis compared with normal human lung. Knockdown of PRAME decreases the expression of E-Cadherin and promotes the proliferation, invasion, and metastasis of lung cancer cells by regulating multiple critical genes, most of which are related to cell migration, including MMP1, CCL2, CTGF, and PLAU. Clinical data analysis reveals that the expression of MMP1 correlates with the clinical features and outcome of lung adenocarcinoma. Taken together, our data demonstrate that PRAME plays a role in preventing the invasion and metastasis of lung adenocarcinoma and novel diagnostic or therapeutic strategies can be developed by targeting PRAME. |
url |
http://europepmc.org/articles/PMC4938541?pdf=render |
work_keys_str_mv |
AT quanhuang preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT haifengwei preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT zhipengwu preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT linli preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT liangfangyao preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT zhengwangsun preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT leili preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT zaijunlin preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT weixu preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT shuaihan preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT wenjiaocao preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT yunfeixu preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT dianwensong preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT xinghaiyang preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis AT jianruxiao preferentiallyexpressedantigenofmelanomapreventslungcancermetastasis |
_version_ |
1725435942199623680 |