CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops

CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops

Abstract Background Recent genome-wide association studies (GWAS) have identified more than 100 loci associated with increased risk of prostate cancer, most of which are in non-coding regions of the genome. Understanding the function of these non-coding risk loci is critical to elucidate the genetic...

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Bibliographic Details
Main Authors: Yu Guo, Andrew A. Perez, Dennis J. Hazelett, Gerhard A. Coetzee, Suhn Kyong Rhie, Peggy J. Farnham
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Genome Biology
Subjects:
CTCF
GWAS SNPs
CRISPR
Prostate cancer
Chromatin looping
Online Access:http://link.springer.com/article/10.1186/s13059-018-1531-0

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