A mixed incoherent feed-forward loop allows conditional regulation of response dynamics.

A mixed incoherent feed-forward loop allows conditional regulation of response dynamics.

Expression of the SodA superoxide dismutase (MnSOD) in Escherichia coli is regulated by superoxide concentration through the SoxRS system and also by Fur (Ferric uptake regulator) through a mixed incoherent feed forward loop (FFL) containing the RyhB small regulatory RNA. In this work I theoreticall...

Full description

Bibliographic Details
Main Author: Szabolcs Semsey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3951346?pdf=render
id doaj-9bcdfe6609964ee9a8dca9c7f5c56af1
record_format Article
spelling doaj-9bcdfe6609964ee9a8dca9c7f5c56af12020-11-25T01:02:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9124310.1371/journal.pone.0091243A mixed incoherent feed-forward loop allows conditional regulation of response dynamics.Szabolcs SemseyExpression of the SodA superoxide dismutase (MnSOD) in Escherichia coli is regulated by superoxide concentration through the SoxRS system and also by Fur (Ferric uptake regulator) through a mixed incoherent feed forward loop (FFL) containing the RyhB small regulatory RNA. In this work I theoretically analyze the function of this feed forward loop as part of the network controlling expression of the two cytoplasmic superoxide dismutases, SodA and SodB. I find that feed forward regulation allows faster response to superoxide stress at low intracellular iron levels compared to iron rich conditions. That is, it can conditionally modulate the response time of a superimposed transcriptional control mechanism.http://europepmc.org/articles/PMC3951346?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Szabolcs Semsey
spellingShingle Szabolcs Semsey
A mixed incoherent feed-forward loop allows conditional regulation of response dynamics.
PLoS ONE
author_facet Szabolcs Semsey
author_sort Szabolcs Semsey
title A mixed incoherent feed-forward loop allows conditional regulation of response dynamics.
title_short A mixed incoherent feed-forward loop allows conditional regulation of response dynamics.
title_full A mixed incoherent feed-forward loop allows conditional regulation of response dynamics.
title_fullStr A mixed incoherent feed-forward loop allows conditional regulation of response dynamics.
title_full_unstemmed A mixed incoherent feed-forward loop allows conditional regulation of response dynamics.
title_sort mixed incoherent feed-forward loop allows conditional regulation of response dynamics.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description Expression of the SodA superoxide dismutase (MnSOD) in Escherichia coli is regulated by superoxide concentration through the SoxRS system and also by Fur (Ferric uptake regulator) through a mixed incoherent feed forward loop (FFL) containing the RyhB small regulatory RNA. In this work I theoretically analyze the function of this feed forward loop as part of the network controlling expression of the two cytoplasmic superoxide dismutases, SodA and SodB. I find that feed forward regulation allows faster response to superoxide stress at low intracellular iron levels compared to iron rich conditions. That is, it can conditionally modulate the response time of a superimposed transcriptional control mechanism.
url http://europepmc.org/articles/PMC3951346?pdf=render
work_keys_str_mv AT szabolcssemsey amixedincoherentfeedforwardloopallowsconditionalregulationofresponsedynamics
AT szabolcssemsey mixedincoherentfeedforwardloopallowsconditionalregulationofresponsedynamics
_version_ 1725205915201699840

Similar Items