Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: a twin study
Abstract Background Obstructive sleep apnoea (OSA) is one of the major sources of the excessive daily sleepiness, cognitive dysfunction, and it increases cardiovascular morbidity and mortality. Previous studies suggested a possible genetic influence, based on questionnaires but no objective genetic...
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doaj-9beaa657d5994d0b9b816cb342abeeda2020-11-25T03:06:43ZengBMCRespiratory Research1465-993X2019-06-012011610.1186/s12931-019-1095-xGenetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: a twin studyMarcell Szily0Adam D. Tarnoki1David L. Tarnoki2Daniel T. Kovacs3Bianka Forgo4Jooyeon Lee5Eunae Kim6Joohon Sung7Laszlo Kunos8Martina Meszaros9Veronika Muller10Andras Bikov11Department of Radiology, Semmelweis UniversityDepartment of Radiology, Semmelweis UniversityDepartment of Radiology, Semmelweis UniversityDepartment of Radiology, Semmelweis UniversityDepartment of Radiology, Semmelweis UniversityComplex Disease and Genome Epidemiology Branch, Department of Public Health Science, School of Public Health, Seoul National UniversityComplex Disease and Genome Epidemiology Branch, Department of Public Health Science, School of Public Health, Seoul National UniversityComplex Disease and Genome Epidemiology Branch, Department of Public Health Science, School of Public Health, Seoul National UniversityDepartment of Pulmonology, Semmelweis UniversityDepartment of Pulmonology, Semmelweis UniversityDepartment of Pulmonology, Semmelweis UniversityDepartment of Pulmonology, Semmelweis UniversityAbstract Background Obstructive sleep apnoea (OSA) is one of the major sources of the excessive daily sleepiness, cognitive dysfunction, and it increases cardiovascular morbidity and mortality. Previous studies suggested a possible genetic influence, based on questionnaires but no objective genetic study was conducted to understand the exact variance underpinned by genetic factors. Methods Seventy-one Hungarian twin pairs involved from the Hungarian Twin Registry (48 monozygotic, MZ and 23 dizygotic, DZ pairs, mean age 51 ± 15 years) underwent overnight polysomnography (Somnoscreen Plus Tele PSG, Somnomedics GMBH, Germany). Apnoea hypopnea index (AHI), respiratory disturbance index (RDI) and oxygen desaturation index (ODI) were registered. Daytime sleepiness was measured with the Epworth Sleepiness Scale (ESS). Bivariate heritability analysis was applied. Results The prevalence of OSA was 41% in our study population. The heritability of the AHI, ODI and RDI ranged between 69% and 83%, while the OSA, defined by an AHI ≥5/h, was itself 73% heritable. The unshared environmental component explained the rest of the variance between 17% and 31%. Daytime sleepiness was mostly determined by the environment, and the variance was influenced in 34% by the additive genetic factors. These associations were present after additional adjustment for body mass index. Conclusion OSA and the indices of OSA severity are heritable, while daytime sleepiness is mostly influenced by environmental factors. Further studies should elucidate whether close relatives of patients with OSA may benefit from early family risk based screening.http://link.springer.com/article/10.1186/s12931-019-1095-xSleep apnoeaSleepinessEnvironmentHeritability |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcell Szily Adam D. Tarnoki David L. Tarnoki Daniel T. Kovacs Bianka Forgo Jooyeon Lee Eunae Kim Joohon Sung Laszlo Kunos Martina Meszaros Veronika Muller Andras Bikov |
spellingShingle |
Marcell Szily Adam D. Tarnoki David L. Tarnoki Daniel T. Kovacs Bianka Forgo Jooyeon Lee Eunae Kim Joohon Sung Laszlo Kunos Martina Meszaros Veronika Muller Andras Bikov Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: a twin study Respiratory Research Sleep apnoea Sleepiness Environment Heritability |
author_facet |
Marcell Szily Adam D. Tarnoki David L. Tarnoki Daniel T. Kovacs Bianka Forgo Jooyeon Lee Eunae Kim Joohon Sung Laszlo Kunos Martina Meszaros Veronika Muller Andras Bikov |
author_sort |
Marcell Szily |
title |
Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: a twin study |
title_short |
Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: a twin study |
title_full |
Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: a twin study |
title_fullStr |
Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: a twin study |
title_full_unstemmed |
Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: a twin study |
title_sort |
genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: a twin study |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-993X |
publishDate |
2019-06-01 |
description |
Abstract Background Obstructive sleep apnoea (OSA) is one of the major sources of the excessive daily sleepiness, cognitive dysfunction, and it increases cardiovascular morbidity and mortality. Previous studies suggested a possible genetic influence, based on questionnaires but no objective genetic study was conducted to understand the exact variance underpinned by genetic factors. Methods Seventy-one Hungarian twin pairs involved from the Hungarian Twin Registry (48 monozygotic, MZ and 23 dizygotic, DZ pairs, mean age 51 ± 15 years) underwent overnight polysomnography (Somnoscreen Plus Tele PSG, Somnomedics GMBH, Germany). Apnoea hypopnea index (AHI), respiratory disturbance index (RDI) and oxygen desaturation index (ODI) were registered. Daytime sleepiness was measured with the Epworth Sleepiness Scale (ESS). Bivariate heritability analysis was applied. Results The prevalence of OSA was 41% in our study population. The heritability of the AHI, ODI and RDI ranged between 69% and 83%, while the OSA, defined by an AHI ≥5/h, was itself 73% heritable. The unshared environmental component explained the rest of the variance between 17% and 31%. Daytime sleepiness was mostly determined by the environment, and the variance was influenced in 34% by the additive genetic factors. These associations were present after additional adjustment for body mass index. Conclusion OSA and the indices of OSA severity are heritable, while daytime sleepiness is mostly influenced by environmental factors. Further studies should elucidate whether close relatives of patients with OSA may benefit from early family risk based screening. |
topic |
Sleep apnoea Sleepiness Environment Heritability |
url |
http://link.springer.com/article/10.1186/s12931-019-1095-x |
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