MicroRNAs in Hepatocellular Carcinoma: Carcinogenesis, Progression, and Therapeutic Target
Hepatocellular carcinoma (HCC) is the third leading cause of death from cancer, with dismal outcomes and an increasing incidence worldwide. Hepatocarcinogenesis is a multistep process that progresses from chronic hepatitis through cirrhosis and/or dysplastic nodule to HCC. However, the detailed mole...
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doaj-9bf5c8358e2449ef8d44ef69593fa81d2020-11-24T23:02:33ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/486407486407MicroRNAs in Hepatocellular Carcinoma: Carcinogenesis, Progression, and Therapeutic TargetChao-Hung Hung0Yi-Chun Chiu1Chien-Hung Chen2Tsung-Hui Hu3Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung Kaohsiung 833, TaiwanDivision of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung Kaohsiung 833, TaiwanDivision of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung Kaohsiung 833, TaiwanDivision of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung Kaohsiung 833, TaiwanHepatocellular carcinoma (HCC) is the third leading cause of death from cancer, with dismal outcomes and an increasing incidence worldwide. Hepatocarcinogenesis is a multistep process that progresses from chronic hepatitis through cirrhosis and/or dysplastic nodule to HCC. However, the detailed molecular pathogenesis remains unclear. MicroRNAs (miRNAs), small noncoding RNAs that regulate the translation of many genes, have emerged as key factors involved in several biological processes, including development, differentiation, and cell proliferation. Recent studies have uncovered the contribution of miRNAs to the cancer pathogenesis, as they can behave as oncogenes or tumor suppressor genes. In addition, other studies have demonstrated their potential values in the clinical management of HCC patients as some miRNAs may be used as prognostic or diagnostic markers. In this review, we summarize current knowledge about the roles of miRNAs in carcinogenesis and progression of HCC. We also discuss the potential application of miRNAs as diagnostic biomarkers and their potential roles in the intervention of HCC.http://dx.doi.org/10.1155/2014/486407 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chao-Hung Hung Yi-Chun Chiu Chien-Hung Chen Tsung-Hui Hu |
spellingShingle |
Chao-Hung Hung Yi-Chun Chiu Chien-Hung Chen Tsung-Hui Hu MicroRNAs in Hepatocellular Carcinoma: Carcinogenesis, Progression, and Therapeutic Target BioMed Research International |
author_facet |
Chao-Hung Hung Yi-Chun Chiu Chien-Hung Chen Tsung-Hui Hu |
author_sort |
Chao-Hung Hung |
title |
MicroRNAs in Hepatocellular Carcinoma: Carcinogenesis, Progression, and Therapeutic Target |
title_short |
MicroRNAs in Hepatocellular Carcinoma: Carcinogenesis, Progression, and Therapeutic Target |
title_full |
MicroRNAs in Hepatocellular Carcinoma: Carcinogenesis, Progression, and Therapeutic Target |
title_fullStr |
MicroRNAs in Hepatocellular Carcinoma: Carcinogenesis, Progression, and Therapeutic Target |
title_full_unstemmed |
MicroRNAs in Hepatocellular Carcinoma: Carcinogenesis, Progression, and Therapeutic Target |
title_sort |
micrornas in hepatocellular carcinoma: carcinogenesis, progression, and therapeutic target |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Hepatocellular carcinoma (HCC) is the third leading cause of death from cancer, with dismal outcomes and an increasing incidence worldwide. Hepatocarcinogenesis is a multistep process that progresses from chronic hepatitis through cirrhosis and/or dysplastic nodule to HCC. However, the detailed molecular pathogenesis remains unclear. MicroRNAs (miRNAs), small noncoding RNAs that regulate the translation of many genes, have emerged as key factors involved in several biological processes, including development, differentiation, and cell proliferation. Recent studies have uncovered the contribution of miRNAs to the cancer pathogenesis, as they can behave as oncogenes or tumor suppressor genes. In addition, other studies have demonstrated their potential values in the clinical management of HCC patients as some miRNAs may be used as prognostic or diagnostic markers. In this review, we summarize current knowledge about the roles of miRNAs in carcinogenesis and progression of HCC. We also discuss the potential application of miRNAs as diagnostic biomarkers and their potential roles in the intervention of HCC. |
url |
http://dx.doi.org/10.1155/2014/486407 |
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