Association of Low Serum <span style="font-variant: small-caps">l</span>-Carnitine Levels with Aortic Stiffness in Patients with Non-Dialysis Chronic Kidney Disease
<span style="font-variant: small-caps;">l</span>-carnitine (LC) is a co-factor in fatty acid metabolism; its role with respect to aortic stiffness (AS) associated with chronic kidney disease (CKD) was unclear. Our aim was to investigate associations between serum LC levels and...
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doaj-9c015e49b3274df291b5ff634b3385c62020-11-25T01:38:26ZengMDPI AGNutrients2072-66432020-09-01122918291810.3390/nu12102918Association of Low Serum <span style="font-variant: small-caps">l</span>-Carnitine Levels with Aortic Stiffness in Patients with Non-Dialysis Chronic Kidney DiseaseYi-Jen Hsieh0Bang-Gee Hsu1Yu-Hsien Lai2Chih-Hsien Wang3Yu-Li Lin4Chiu-Huang Kuo5Jen-Pi Tsai6Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97010, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97010, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97010, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97010, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97010, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97010, TaiwanSchool of Medicine, Tzu Chi University, Hualien 97004, Taiwan<span style="font-variant: small-caps;">l</span>-carnitine (LC) is a co-factor in fatty acid metabolism; its role with respect to aortic stiffness (AS) associated with chronic kidney disease (CKD) was unclear. Our aim was to investigate associations between serum LC levels and AS in patients with non-dialysis CKD stage 3–5. The AS patients were those with carotid-femoral pulse wave velocities (cfPWV) >10 m/s; those with cfPWV ≤10 m/s were included as controls. Serum LC was measured by liquid chromatography and mass spectrometry. Of 136 CKD patients, the 44 (32.4%) with AS were older, exhibited higher rates of diabetes, and had elevated diastolic and systolic blood pressures (SBP), elevated fasting glucose levels and lower levels of serum LC compared to controls. Multivariable logistic regression revealed that serum LC (odds ratio [OR] = 0.949, 95% confidence interval [CI] 0.911–0.988, <i>p</i> = 0.011) and age (OR = 1.055, 95% CI 1.013–1.099, <i>p</i> = 0.009) were independent predictors of AS. Multivariable stepwise linear regression revealed significant positive (age and SBP) and negative (serum LC) correlations with cfPWV. The area under the curve of serum LC as a means to predict AS in CKD patients was 0.657 (95% CI 0.571–0.736, <i>p</i> = 0.0009). We concluded that low serum LC is a significant predictor of AS in patients diagnosed with CKD.https://www.mdpi.com/2072-6643/12/10/2918aortic stiffnesscarotid-femoral pulse wave velocitychronic kidney disease<span style="font-variant: small-caps">l</span>-carnitine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi-Jen Hsieh Bang-Gee Hsu Yu-Hsien Lai Chih-Hsien Wang Yu-Li Lin Chiu-Huang Kuo Jen-Pi Tsai |
spellingShingle |
Yi-Jen Hsieh Bang-Gee Hsu Yu-Hsien Lai Chih-Hsien Wang Yu-Li Lin Chiu-Huang Kuo Jen-Pi Tsai Association of Low Serum <span style="font-variant: small-caps">l</span>-Carnitine Levels with Aortic Stiffness in Patients with Non-Dialysis Chronic Kidney Disease Nutrients aortic stiffness carotid-femoral pulse wave velocity chronic kidney disease <span style="font-variant: small-caps">l</span>-carnitine |
author_facet |
Yi-Jen Hsieh Bang-Gee Hsu Yu-Hsien Lai Chih-Hsien Wang Yu-Li Lin Chiu-Huang Kuo Jen-Pi Tsai |
author_sort |
Yi-Jen Hsieh |
title |
Association of Low Serum <span style="font-variant: small-caps">l</span>-Carnitine Levels with Aortic Stiffness in Patients with Non-Dialysis Chronic Kidney Disease |
title_short |
Association of Low Serum <span style="font-variant: small-caps">l</span>-Carnitine Levels with Aortic Stiffness in Patients with Non-Dialysis Chronic Kidney Disease |
title_full |
Association of Low Serum <span style="font-variant: small-caps">l</span>-Carnitine Levels with Aortic Stiffness in Patients with Non-Dialysis Chronic Kidney Disease |
title_fullStr |
Association of Low Serum <span style="font-variant: small-caps">l</span>-Carnitine Levels with Aortic Stiffness in Patients with Non-Dialysis Chronic Kidney Disease |
title_full_unstemmed |
Association of Low Serum <span style="font-variant: small-caps">l</span>-Carnitine Levels with Aortic Stiffness in Patients with Non-Dialysis Chronic Kidney Disease |
title_sort |
association of low serum <span style="font-variant: small-caps">l</span>-carnitine levels with aortic stiffness in patients with non-dialysis chronic kidney disease |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-09-01 |
description |
<span style="font-variant: small-caps;">l</span>-carnitine (LC) is a co-factor in fatty acid metabolism; its role with respect to aortic stiffness (AS) associated with chronic kidney disease (CKD) was unclear. Our aim was to investigate associations between serum LC levels and AS in patients with non-dialysis CKD stage 3–5. The AS patients were those with carotid-femoral pulse wave velocities (cfPWV) >10 m/s; those with cfPWV ≤10 m/s were included as controls. Serum LC was measured by liquid chromatography and mass spectrometry. Of 136 CKD patients, the 44 (32.4%) with AS were older, exhibited higher rates of diabetes, and had elevated diastolic and systolic blood pressures (SBP), elevated fasting glucose levels and lower levels of serum LC compared to controls. Multivariable logistic regression revealed that serum LC (odds ratio [OR] = 0.949, 95% confidence interval [CI] 0.911–0.988, <i>p</i> = 0.011) and age (OR = 1.055, 95% CI 1.013–1.099, <i>p</i> = 0.009) were independent predictors of AS. Multivariable stepwise linear regression revealed significant positive (age and SBP) and negative (serum LC) correlations with cfPWV. The area under the curve of serum LC as a means to predict AS in CKD patients was 0.657 (95% CI 0.571–0.736, <i>p</i> = 0.0009). We concluded that low serum LC is a significant predictor of AS in patients diagnosed with CKD. |
topic |
aortic stiffness carotid-femoral pulse wave velocity chronic kidney disease <span style="font-variant: small-caps">l</span>-carnitine |
url |
https://www.mdpi.com/2072-6643/12/10/2918 |
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