Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe COVID-19: A case report

• Main Authors: Marco Franzetti, Ugo Pozzetti, Manuela Carugati, Alessandro Pandolfo, Chiara Molteni, Paolo Faccioli, Gioacchino Castaldo, Ernesto Longoni, Valentina Ormas, Enrico Iemoli, Stefania Piconi
• Format: Article
• Language: English
• Published: Elsevier 2020-08-01
• Series: International Journal of Infectious Diseases
• Subjects: Novel coronavirus disease 2019 (COVID-19); Cytokine-release syndrome; Interleukin-1 receptor antagonist; Anakinra; Remdesivir
• Online Access: http://www.sciencedirect.com/science/article/pii/S120197122030357X

We report the first successful treatment with the IL-1 receptor antagonist anakinra, in association with the most promising and available antiviral therapy, of a severe case of novel coronavirus disease 2019 (COVID-19). We describe the diagnosis, clinical course, and management of the case, including the respiratory failure at presentation, the progression to a scenario characterized by profound inflammatory dysregulation similar to that observed during macrophage activation syndrome, and the clinical improvement after treatment with the IL-1 receptor antagonist anakinra. This case highlights the high tolerability and the interesting immunomodulatory profile of the IL-1 receptor antagonist anakinra in the setting of severe COVID-19 associated with remdesivir therapy. Further studies are needed to confirm the safety and efficacy of this combination strategy in the treatment of this emerging infection.