Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: A systematic review and meta-regression.
BACKGROUND:Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VF) in patients with systemic lupus erythematosus (SLE). Therefore, the objectives of this systematic review and meta-regression were: 1) to compare BMD betw...
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doaj-9c095d846165491dafea4cfea0bf1fe72020-11-25T02:47:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01136e019611310.1371/journal.pone.0196113Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: A systematic review and meta-regression.Claudia Mendoza-PintoAdriana Rojas-VillarragaNicolás Molano-GonzálezErick A Jiménez-HerreraMaría de la Luz León-VázquezÁlvaro Montiel-JarquínMario García-CarrascoRicard CerveraBACKGROUND:Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VF) in patients with systemic lupus erythematosus (SLE). Therefore, the objectives of this systematic review and meta-regression were: 1) to compare BMD between SLE patients and healthy controls and 2) to evaluate the relationship between BMD and glucocorticoid therapy and VF in SLE patients. METHODS AND FINDINGS:Articles were identified from electronic databases (PubMed, Embase, VHL, SciELO and the Cochrane Library). Prospective longitudinal and cross-sectional studies were considered for review. We evaluated the quality of the evidence included using the Oxford Centre for evidence-based medicine (EBM) Levels of Evidence. In total, 38 articles were identified and analyzed (3442 SLE cases and 6198 controls) in the analysis of BMD (9232 women and 408 men). There were significant differences in mean BMD between SLE patients and controls. BMD mean difference in cases/controls: -0.0566 95% CI (-0.071, -0.0439; p = < 0.0001). When only SLE patients were analyzed, the BMD did not significantly differ between patients who had or had not received glucocorticoid (GCT) therapy. 694 SLE patients were included in the analysis of VF (189 with VF vs. 505 without VF). Patients with VF had lower BMD than patients without VF (BMD mean difference without VF/with VF: 0.033 (95%CI: 0.006-0.060); p-value: 0.0156). CONCLUSIONS:Patients with SLE had lower BMD than healthy controls. Moreover, SLE patients with VF had lower BMD than patients without VF. However, our data did not show that GCT therapy had an impact on BMD.http://europepmc.org/articles/PMC5999233?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claudia Mendoza-Pinto Adriana Rojas-Villarraga Nicolás Molano-González Erick A Jiménez-Herrera María de la Luz León-Vázquez Álvaro Montiel-Jarquín Mario García-Carrasco Ricard Cervera |
spellingShingle |
Claudia Mendoza-Pinto Adriana Rojas-Villarraga Nicolás Molano-González Erick A Jiménez-Herrera María de la Luz León-Vázquez Álvaro Montiel-Jarquín Mario García-Carrasco Ricard Cervera Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: A systematic review and meta-regression. PLoS ONE |
author_facet |
Claudia Mendoza-Pinto Adriana Rojas-Villarraga Nicolás Molano-González Erick A Jiménez-Herrera María de la Luz León-Vázquez Álvaro Montiel-Jarquín Mario García-Carrasco Ricard Cervera |
author_sort |
Claudia Mendoza-Pinto |
title |
Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: A systematic review and meta-regression. |
title_short |
Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: A systematic review and meta-regression. |
title_full |
Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: A systematic review and meta-regression. |
title_fullStr |
Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: A systematic review and meta-regression. |
title_full_unstemmed |
Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: A systematic review and meta-regression. |
title_sort |
bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: a systematic review and meta-regression. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
BACKGROUND:Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VF) in patients with systemic lupus erythematosus (SLE). Therefore, the objectives of this systematic review and meta-regression were: 1) to compare BMD between SLE patients and healthy controls and 2) to evaluate the relationship between BMD and glucocorticoid therapy and VF in SLE patients. METHODS AND FINDINGS:Articles were identified from electronic databases (PubMed, Embase, VHL, SciELO and the Cochrane Library). Prospective longitudinal and cross-sectional studies were considered for review. We evaluated the quality of the evidence included using the Oxford Centre for evidence-based medicine (EBM) Levels of Evidence. In total, 38 articles were identified and analyzed (3442 SLE cases and 6198 controls) in the analysis of BMD (9232 women and 408 men). There were significant differences in mean BMD between SLE patients and controls. BMD mean difference in cases/controls: -0.0566 95% CI (-0.071, -0.0439; p = < 0.0001). When only SLE patients were analyzed, the BMD did not significantly differ between patients who had or had not received glucocorticoid (GCT) therapy. 694 SLE patients were included in the analysis of VF (189 with VF vs. 505 without VF). Patients with VF had lower BMD than patients without VF (BMD mean difference without VF/with VF: 0.033 (95%CI: 0.006-0.060); p-value: 0.0156). CONCLUSIONS:Patients with SLE had lower BMD than healthy controls. Moreover, SLE patients with VF had lower BMD than patients without VF. However, our data did not show that GCT therapy had an impact on BMD. |
url |
http://europepmc.org/articles/PMC5999233?pdf=render |
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