A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
Induced neurons, but not induced pluripotent stem cell (iPSC)-derived neurons, preserve age-related traits. Here, the authors demonstrate that blood-derived induced neural stem cells (iNSCs), despite lacking a pluripotency transit, lose age-related signatures.
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Nature Publishing Group
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06398-5 |
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doaj-9c09e47ee2e347998c074816930580952021-05-11T09:30:03ZengNature Publishing GroupNature Communications2041-17232018-10-019111510.1038/s41467-018-06398-5A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenationChao Sheng0Johannes Jungverdorben1Hendrik Wiethoff2Qiong Lin3Lea J. Flitsch4Daniela Eckert5Matthias Hebisch6Julia Fischer7Jaideep Kesavan8Beatrice Weykopf9Linda Schneider10Dominik Holtkamp11Heinz Beck12Andreas Till13Ullrich Wüllner14Michael J. Ziller15Wolfgang Wagner16Michael Peitz17Oliver Brüstle18Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterHelmholtz-Institute for Biomedical Engineering, RWTH Aachen University Medical SchoolInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterInstitute of Experimental Epileptology and Cognition Research, Life & Brain Center, University of Bonn Medical CenterInstitute of Experimental Epileptology and Cognition Research, Life & Brain Center, University of Bonn Medical CenterInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterGerman Center for Neurodegenerative Diseases (DZNE)Max Planck Institute of PsychiatryHelmholtz-Institute for Biomedical Engineering, RWTH Aachen University Medical SchoolInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical CenterInduced neurons, but not induced pluripotent stem cell (iPSC)-derived neurons, preserve age-related traits. Here, the authors demonstrate that blood-derived induced neural stem cells (iNSCs), despite lacking a pluripotency transit, lose age-related signatures.https://doi.org/10.1038/s41467-018-06398-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chao Sheng Johannes Jungverdorben Hendrik Wiethoff Qiong Lin Lea J. Flitsch Daniela Eckert Matthias Hebisch Julia Fischer Jaideep Kesavan Beatrice Weykopf Linda Schneider Dominik Holtkamp Heinz Beck Andreas Till Ullrich Wüllner Michael J. Ziller Wolfgang Wagner Michael Peitz Oliver Brüstle |
| spellingShingle |
Chao Sheng Johannes Jungverdorben Hendrik Wiethoff Qiong Lin Lea J. Flitsch Daniela Eckert Matthias Hebisch Julia Fischer Jaideep Kesavan Beatrice Weykopf Linda Schneider Dominik Holtkamp Heinz Beck Andreas Till Ullrich Wüllner Michael J. Ziller Wolfgang Wagner Michael Peitz Oliver Brüstle A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation Nature Communications |
| author_facet |
Chao Sheng Johannes Jungverdorben Hendrik Wiethoff Qiong Lin Lea J. Flitsch Daniela Eckert Matthias Hebisch Julia Fischer Jaideep Kesavan Beatrice Weykopf Linda Schneider Dominik Holtkamp Heinz Beck Andreas Till Ullrich Wüllner Michael J. Ziller Wolfgang Wagner Michael Peitz Oliver Brüstle |
| author_sort |
Chao Sheng |
| title |
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation |
| title_short |
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation |
| title_full |
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation |
| title_fullStr |
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation |
| title_full_unstemmed |
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation |
| title_sort |
stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-10-01 |
| description |
Induced neurons, but not induced pluripotent stem cell (iPSC)-derived neurons, preserve age-related traits. Here, the authors demonstrate that blood-derived induced neural stem cells (iNSCs), despite lacking a pluripotency transit, lose age-related signatures. |
| url |
https://doi.org/10.1038/s41467-018-06398-5 |
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