Serum 25-hydroxyvitamin D levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant women
Background: Worldwide there is a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency and has been associated with adverse outcomes during pregnancy. Objective: This is a nested, case–control study in a longitudinal cohort to compare the serum 25OHD levels and other biomarkers throughout pregn...
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Bioscientifica
2018-05-01
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Series: | Endocrine Connections |
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Online Access: | http://www.endocrineconnections.com/content/7/5/698.full |
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language |
English |
format |
Article |
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author |
Yessica Agudelo-Zapata Luis Miguel Maldonado-Acosta Héctor Fabio Sandoval-Alzate Natalia Elvira Poveda María Fernanda Garcés Jonathan Alexander Cortés-Vásquez Andrés Felipe Linares-Vaca Carlos Alejandro Mancera-Rodríguez Shahar Alexandra Perea-Ariza Karen Yuliana Ramírez-Iriarte Camilo Andrés Castro-Saldarriaga Juan Manuel Arteaga-Diaz Roberto Franco-Vega Edith Ángel–Müller Arturo José Parada-Baños Jorge E Caminos |
spellingShingle |
Yessica Agudelo-Zapata Luis Miguel Maldonado-Acosta Héctor Fabio Sandoval-Alzate Natalia Elvira Poveda María Fernanda Garcés Jonathan Alexander Cortés-Vásquez Andrés Felipe Linares-Vaca Carlos Alejandro Mancera-Rodríguez Shahar Alexandra Perea-Ariza Karen Yuliana Ramírez-Iriarte Camilo Andrés Castro-Saldarriaga Juan Manuel Arteaga-Diaz Roberto Franco-Vega Edith Ángel–Müller Arturo José Parada-Baños Jorge E Caminos Serum 25-hydroxyvitamin D levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant women Endocrine Connections 25 hydroxyvitamin D pregnancy preeclampsia menstrual cycle |
author_facet |
Yessica Agudelo-Zapata Luis Miguel Maldonado-Acosta Héctor Fabio Sandoval-Alzate Natalia Elvira Poveda María Fernanda Garcés Jonathan Alexander Cortés-Vásquez Andrés Felipe Linares-Vaca Carlos Alejandro Mancera-Rodríguez Shahar Alexandra Perea-Ariza Karen Yuliana Ramírez-Iriarte Camilo Andrés Castro-Saldarriaga Juan Manuel Arteaga-Diaz Roberto Franco-Vega Edith Ángel–Müller Arturo José Parada-Baños Jorge E Caminos |
author_sort |
Yessica Agudelo-Zapata |
title |
Serum 25-hydroxyvitamin D levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant women |
title_short |
Serum 25-hydroxyvitamin D levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant women |
title_full |
Serum 25-hydroxyvitamin D levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant women |
title_fullStr |
Serum 25-hydroxyvitamin D levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant women |
title_full_unstemmed |
Serum 25-hydroxyvitamin D levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant women |
title_sort |
serum 25-hydroxyvitamin d levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant women |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2018-05-01 |
description |
Background: Worldwide there is a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency and has been associated with adverse outcomes during pregnancy.
Objective: This is a nested, case–control study in a longitudinal cohort to compare the serum 25OHD levels and other biomarkers throughout pregnancy in a group of 20 preeclamptic women and 61 healthy pregnant women. An additional group of 29 healthy non-pregnant women were also studied during the two phases of the menstrual cycle.
Results: Mean 25OHD levels in non-pregnant women were 31.9 ng/mL and 34.9 ng/mL during follicular and luteal phase, respectively (P < 0.01). Mean serum 25OHD levels in healthy pregnant women were 26.5, 30.1 and 31.9 ng/mL, at first, second and third trimester, respectively (P < 0.001). The first trimester levels of 25OHD were lower than those of healthy non-pregnant women (P < 0.001), showing a significant recovery at third trimester. In the group of healthy pregnant women, the 25OHD levels were 25.7 ng/mL and 27.2 ng/mL at 3 and 6 months postpartum, respectively; both values were lower than those observed in the non-pregnant women (P < 0.001). In preeclamptic women, 25OHD serum levels were similar to those of healthy pregnant women; nevertheless, they remained almost unchanged throughout pregnancy.
Conclusion: There were no significant differences between healthy and preeclamptic pregnant women in terms of 25OHD levels throughout the pregnancy. Serum 25OHD levels in non-pregnant women were higher during luteal phase compared with follicular phase. The 25OHD levels of non-pregnant women tended to be higher than those of pregnant women. |
topic |
25 hydroxyvitamin D pregnancy preeclampsia menstrual cycle |
url |
http://www.endocrineconnections.com/content/7/5/698.full |
work_keys_str_mv |
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doaj-9c0b62fbcab642b797e3a862a41d43f62020-11-24T21:39:09ZengBioscientificaEndocrine Connections2049-36142049-36142018-05-0175698707https://doi.org/10.1530/EC-18-0055Serum 25-hydroxyvitamin D levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant womenYessica Agudelo-Zapata0Luis Miguel Maldonado-Acosta1Héctor Fabio Sandoval-Alzate2Natalia Elvira Poveda3María Fernanda Garcés4Jonathan Alexander Cortés-Vásquez5Andrés Felipe Linares-Vaca6Carlos Alejandro Mancera-Rodríguez7Shahar Alexandra Perea-Ariza8Karen Yuliana Ramírez-Iriarte9Camilo Andrés Castro-Saldarriaga10Juan Manuel Arteaga-Diaz11Roberto Franco-Vega12Edith Ángel–Müller13Arturo José Parada-Baños14Jorge E Caminos15Division of Endocrinology, Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDivision of Endocrinology, Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDepartment of Human Nutrition, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDivision of Endocrinology, Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDivision of Endocrinology, Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDepartment of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDepartment of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, ColombiaBackground: Worldwide there is a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency and has been associated with adverse outcomes during pregnancy. Objective: This is a nested, case–control study in a longitudinal cohort to compare the serum 25OHD levels and other biomarkers throughout pregnancy in a group of 20 preeclamptic women and 61 healthy pregnant women. An additional group of 29 healthy non-pregnant women were also studied during the two phases of the menstrual cycle. Results: Mean 25OHD levels in non-pregnant women were 31.9 ng/mL and 34.9 ng/mL during follicular and luteal phase, respectively (P < 0.01). Mean serum 25OHD levels in healthy pregnant women were 26.5, 30.1 and 31.9 ng/mL, at first, second and third trimester, respectively (P < 0.001). The first trimester levels of 25OHD were lower than those of healthy non-pregnant women (P < 0.001), showing a significant recovery at third trimester. In the group of healthy pregnant women, the 25OHD levels were 25.7 ng/mL and 27.2 ng/mL at 3 and 6 months postpartum, respectively; both values were lower than those observed in the non-pregnant women (P < 0.001). In preeclamptic women, 25OHD serum levels were similar to those of healthy pregnant women; nevertheless, they remained almost unchanged throughout pregnancy. Conclusion: There were no significant differences between healthy and preeclamptic pregnant women in terms of 25OHD levels throughout the pregnancy. Serum 25OHD levels in non-pregnant women were higher during luteal phase compared with follicular phase. The 25OHD levels of non-pregnant women tended to be higher than those of pregnant women.http://www.endocrineconnections.com/content/7/5/698.full25 hydroxyvitamin Dpregnancypreeclampsiamenstrual cycle |