Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

Dental caries and periodontitis are among the most common medical conditions. Here, the authors report a GWAS for measures of oral health that reveals 47 risk loci for caries, find genetic correlation with 31 other complex traits and use Mendelian randomization analyses to explore potential causal r...

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Main Authors:	Dmitry Shungin, Simon Haworth, Kimon Divaris, Cary S. Agler, Yoichiro Kamatani, Myoung Keun Lee, Kelsey Grinde, George Hindy, Viivi Alaraudanjoki, Paula Pesonen, Alexander Teumer, Birte Holtfreter, Saori Sakaue, Jun Hirata, Yau-Hua Yu, Paul M. Ridker, Franco Giulianini, Daniel I. Chasman, Patrik K. E. Magnusson, Takeaki Sudo, Yukinori Okada, Uwe Völker, Thomas Kocher, Vuokko Anttonen, Marja-Liisa Laitala, Marju Orho-Melander, Tamar Sofer, John R. Shaffer, Alexandre Vieira, Mary L. Marazita, Michiaki Kubo, Yasushi Furuichi, Kari E. North, Steve Offenbacher, Erik Ingelsson, Paul W. Franks, Nicholas J. Timpson, Ingegerd Johansson
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10630-1

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spelling	doaj-9c0e19f3136944e4b0b2db9b41f364852021-05-11T11:27:18ZengNature Publishing GroupNature Communications2041-17232019-06-0110111310.1038/s41467-019-10630-1Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported dataDmitry Shungin0Simon Haworth1Kimon Divaris2Cary S. Agler3Yoichiro Kamatani4Myoung Keun Lee5Kelsey Grinde6George Hindy7Viivi Alaraudanjoki8Paula Pesonen9Alexander Teumer10Birte Holtfreter11Saori Sakaue12Jun Hirata13Yau-Hua Yu14Paul M. Ridker15Franco Giulianini16Daniel I. Chasman17Patrik K. E. Magnusson18Takeaki Sudo19Yukinori Okada20Uwe Völker21Thomas Kocher22Vuokko Anttonen23Marja-Liisa Laitala24Marju Orho-Melander25Tamar Sofer26John R. Shaffer27Alexandre Vieira28Mary L. Marazita29Michiaki Kubo30Yasushi Furuichi31Kari E. North32Steve Offenbacher33Erik Ingelsson34Paul W. Franks35Nicholas J. Timpson36Ingegerd Johansson37Department of Odontology, Umeå UniversityMedical Research Council Integrative Epidemiology Unit, Bristol Medical SchoolDepartment of Pediatric Dentistry, School of Dentistry, University of North CarolinaDepartment of Oral and Craniofacial Health Sciences, University of North CarolinaRIKEN Center for Integrative Medical SciencesCenter for Craniofacial and Dental Genetics, School of Dental Medicine, University of PittsburghDepartment of Biostatistics, University of WashingtonLund UniversityResearch Unit of Oral Health Sciences University of OuluInfrastructure for Population Studies, Faculty of Medicine, University of OuluInstitute for Community Medicine, University Medicine GreifswaldDepartment of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry University Medicine GreifswaldDepartment of Statistical Genetics, Osaka University Graduate School of MedicineDepartment of Statistical Genetics, Osaka University Graduate School of MedicineDivision of Preventive Medicine, Brigham and Women’s HospitalDivision of Preventive Medicine, Brigham and Women’s HospitalDivision of Preventive Medicine, Brigham and Women’s HospitalDivision of Preventive Medicine, Brigham and Women’s HospitalDepartment of Medical Epidemiology and Biostatistics, Karolinska InstituetDepartment of Periodontology, Graduate School of Medical and Dental Science of Tokyo Medical and Dental UniversityDepartment of Statistical Genetics, Osaka University Graduate School of MedicineDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine GreifswaldDepartment of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry University Medicine GreifswaldResearch Unit of Oral Health Sciences University of OuluResearch Unit of Oral Health Sciences University of OuluLund UniversityHarvard Medical SchoolCenter for Craniofacial and Dental Genetics, School of Dental Medicine, University of PittsburghDepartment of Oral Biology, University of PittsburghCenter for Craniofacial and Dental Genetics, School of Dental Medicine, University of PittsburghRIKEN Center for Integrative Medical SciencesDepartment of Oral Rehabilitation, Division of Periodontology and Endodontology, School of Dentistry, Health Sciences University of HokkaidoDepartment of Epidemiology, University of North CarolinaDepartment of Periodontology, University of North CarolinaDepartment of Medicine, Stanford University School of MedicineDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund UniversityMedical Research Council Integrative Epidemiology Unit, Bristol Medical SchoolDepartment of Odontology, Umeå UniversityDental caries and periodontitis are among the most common medical conditions. Here, the authors report a GWAS for measures of oral health that reveals 47 risk loci for caries, find genetic correlation with 31 other complex traits and use Mendelian randomization analyses to explore potential causal relationships.https://doi.org/10.1038/s41467-019-10630-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dmitry Shungin Simon Haworth Kimon Divaris Cary S. Agler Yoichiro Kamatani Myoung Keun Lee Kelsey Grinde George Hindy Viivi Alaraudanjoki Paula Pesonen Alexander Teumer Birte Holtfreter Saori Sakaue Jun Hirata Yau-Hua Yu Paul M. Ridker Franco Giulianini Daniel I. Chasman Patrik K. E. Magnusson Takeaki Sudo Yukinori Okada Uwe Völker Thomas Kocher Vuokko Anttonen Marja-Liisa Laitala Marju Orho-Melander Tamar Sofer John R. Shaffer Alexandre Vieira Mary L. Marazita Michiaki Kubo Yasushi Furuichi Kari E. North Steve Offenbacher Erik Ingelsson Paul W. Franks Nicholas J. Timpson Ingegerd Johansson
spellingShingle	Dmitry Shungin Simon Haworth Kimon Divaris Cary S. Agler Yoichiro Kamatani Myoung Keun Lee Kelsey Grinde George Hindy Viivi Alaraudanjoki Paula Pesonen Alexander Teumer Birte Holtfreter Saori Sakaue Jun Hirata Yau-Hua Yu Paul M. Ridker Franco Giulianini Daniel I. Chasman Patrik K. E. Magnusson Takeaki Sudo Yukinori Okada Uwe Völker Thomas Kocher Vuokko Anttonen Marja-Liisa Laitala Marju Orho-Melander Tamar Sofer John R. Shaffer Alexandre Vieira Mary L. Marazita Michiaki Kubo Yasushi Furuichi Kari E. North Steve Offenbacher Erik Ingelsson Paul W. Franks Nicholas J. Timpson Ingegerd Johansson Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data Nature Communications
author_facet	Dmitry Shungin Simon Haworth Kimon Divaris Cary S. Agler Yoichiro Kamatani Myoung Keun Lee Kelsey Grinde George Hindy Viivi Alaraudanjoki Paula Pesonen Alexander Teumer Birte Holtfreter Saori Sakaue Jun Hirata Yau-Hua Yu Paul M. Ridker Franco Giulianini Daniel I. Chasman Patrik K. E. Magnusson Takeaki Sudo Yukinori Okada Uwe Völker Thomas Kocher Vuokko Anttonen Marja-Liisa Laitala Marju Orho-Melander Tamar Sofer John R. Shaffer Alexandre Vieira Mary L. Marazita Michiaki Kubo Yasushi Furuichi Kari E. North Steve Offenbacher Erik Ingelsson Paul W. Franks Nicholas J. Timpson Ingegerd Johansson
author_sort	Dmitry Shungin
title	Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
title_short	Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
title_full	Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
title_fullStr	Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
title_full_unstemmed	Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
title_sort	genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-06-01
description	Dental caries and periodontitis are among the most common medical conditions. Here, the authors report a GWAS for measures of oral health that reveals 47 risk loci for caries, find genetic correlation with 31 other complex traits and use Mendelian randomization analyses to explore potential causal relationships.
url	https://doi.org/10.1038/s41467-019-10630-1
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Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

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