A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes, including metastasis and therapy resistance. CB002 and structural-analogs restore p53 signaling in tumors with mutant-p53 but we find that unlike other xanthines such as caffeine, pentoxifylline,...

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Bibliographic Details
Main Authors: Liz Hernandez Borrero, David T Dicker, John Santiago, Jennifer Sanders, Xiaobing Tian, Nagib Ahsan, Avital Lev, Lanlan Zhou, Wafik S El-Deiry
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
p53
cancer
therapy
xanthines
CB002
noxa
Online Access:https://elifesciences.org/articles/70429

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