Direct Single-Cell Analysis of Human Polar Bodies and Cleavage-Stage Embryos Reveals No Evidence of the Telomere Theory of Reproductive Ageing in Relation to Aneuploidy Generation
Reproductive ageing in women, particularly after the age of 35, is associated with an exponential increase in the proportion of chromosomally abnormal oocytes produced. Several hypotheses have attempted to explain this observation, including the ‘limited oocyte pool’ hypothesis a...
Main Authors: | Kara Turner, Colleen Lynch, Hannah Rouse, Vimal Vasu, Darren K. Griffin |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-02-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/8/2/163 |
Similar Items
-
Telomere Biology and Human Phenotype
by: Kara J. Turner, et al.
Published: (2019-01-01) -
Chromosomal Aneuploidies and Early Embryonic Developmental Arrest
by: Maria Maurer, et al.
Published: (2015-10-01) -
Can telomere shortening be the main indicator of non-viable fetus elimination?
by: Nataliya Huleyuk, et al.
Published: (2018-01-01) -
Correlation between embryo morphology and development and chromosomal complement
by: Vy Phan, et al.
Published: (2014-06-01) -
A Rapid NGS-Based Preimplantation Genetic Testing for Chromosomal Abnormalities in Day-3 Blastomere Biopsy Allows Embryo Transfer Within the Same Treatment Cycle
by: Yinghui Ye, et al.
Published: (2021-02-01)