FDG-PET hypermetabolism is associated with higher tau-PET in mild cognitive impairment at low amyloid-PET levels

• Main Authors: Anna Rubinski, Nicolai Franzmeier, Julia Neitzel, Michael Ewers, the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
• Format: Article
• Language: English
• Published: BMC 2020-10-01
• Series: Alzheimer’s Research & Therapy
• Subjects: FDG-PET; Hypermetabolism; Tau-PET; Amyloid-PET; Hyperactivation; Mild cognitive impairment
• Online Access: http://link.springer.com/article/10.1186/s13195-020-00702-6

Abstract Background FDG-PET hypermetabolism can be observed in mild cognitive impairment (MCI), but the link to primary pathologies of Alzheimer’s diseases (AD) including amyloid and tau is unclear. Methods Using voxel-based regression, we assessed local interactions between amyloid- and tau-PET on spatially matched FDG-PET in 72 MCI patients. Control groups included cerebrospinal fluid biomarker characterized cognitively normal (CN, n = 70) and AD dementia subjects (n = 95). Results In MCI, significant amyloid-PET by tau-PET interactions were found in frontal, lateral temporal, and posterior parietal regions, where higher local tau-PET was associated with higher spatially corresponding FDG-PET at low levels of local amyloid-PET. FDG-PET in brain regions with a significant local amyloid- by tau-PET interaction was higher compared to that in CN and AD dementia and associated with lower episodic memory. Conclusion Higher tau-PET in the presence of low amyloid-PET is associated with abnormally increased glucose metabolism that is accompanied by episodic memory impairment.