Combined neutrophil/platelet/lymphocyte/differentiation score predicts chemosensitivity in advanced gastric cancer
Abstract Background Gastric cancer is common in developing regions, and we hope to find out an economical but practical prognostic indicator. It was reported that pre-treatment peripheral neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), as well as differentiation status,...
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doaj-9c2ebdb3d79648828bb84efe80aa15a92020-11-25T00:35:18ZengBMCBMC Cancer1471-24072018-05-011811910.1186/s12885-018-4414-6Combined neutrophil/platelet/lymphocyte/differentiation score predicts chemosensitivity in advanced gastric cancerZhenhua Huang0Yantan Liu1Chen Yang2Xiaoyin Li3Changqie Pan4Jinjun Rao5Nailin Li6Wangjun Liao7Li Lin8Department of Oncology, Nanfang Hospital, Southern Medical UniversityDepartment of Oncology, Nanfang Hospital, Southern Medical UniversityDepartment of Oncology, Nanfang Hospital, Southern Medical UniversityDepartment of Oncology, Nanfang Hospital, Southern Medical UniversityDepartment of Oncology, Nanfang Hospital, Southern Medical UniversityKey laboratory of new drug screening of Guangdong Province, School of Pharmaceutical Sciences, Southern Medical UniversityDepartment of Medicine-Solna, Karolinska Institute, Clinical Pharmacology Group, Karolinska University Hospital-SolnaDepartment of Oncology, Nanfang Hospital, Southern Medical UniversityDepartment of Oncology, Nanfang Hospital, Southern Medical UniversityAbstract Background Gastric cancer is common in developing regions, and we hope to find out an economical but practical prognostic indicator. It was reported that pre-treatment peripheral neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), as well as differentiation status, were associated with cancer progression. Hence, we introduced a novel combined Neutrophil/platelet/lymphocyte/differentiation Score (cNPLDS) to improve the prediction value of palliative chemotherapeutic response in advanced gastric cancer. Methods According to statistical sample size estimation, 136 primary diagnosed unresectable advanced ptaients were included for a retrospective study. The follow-up end-point was progression free survival (PFS) during the first-line palliative chemotherapy. Differentiation stratified patients into well, medium and poor groups by score 1 to 3, while patients with neither elevated NLR and PLR, only one elevated, or both elevated were of the combined NLR-PLR score (cNPS) 1 to 3, respectively. The cNPLDS was calculated by multiplying the tumor differentiation score and cNPS. Results Determined by the receiver operating characteristic (ROC) curve, the optimal cut-off points for NLR and PLR were 3.04 and 223. Through univariate analysis and survival analysis, poor differentiation, high NLR, high PLR, high cNPS, and high cNPLDS respectively indicated inferior PFS during the first-line palliative chemotherapy. Patients were furhter classified into low to high risk groups by cNPLDS. Groups of elevated NLR, PLR, cNPS, and cNPLDS showed lower disease control rate. Compared to other parameters, cNPLDS significantly improved the accuracy in predicing the first-progression. Conclusions This study indicates that the novel parameter cNPLDS is superior to NLR or PLR alone, or even cNPS, in predicting the first-line chemosensitivity in advanced gastric cancer.http://link.springer.com/article/10.1186/s12885-018-4414-6Gastric cancerChemosensitivityNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioTumor differentiation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhenhua Huang Yantan Liu Chen Yang Xiaoyin Li Changqie Pan Jinjun Rao Nailin Li Wangjun Liao Li Lin |
spellingShingle |
Zhenhua Huang Yantan Liu Chen Yang Xiaoyin Li Changqie Pan Jinjun Rao Nailin Li Wangjun Liao Li Lin Combined neutrophil/platelet/lymphocyte/differentiation score predicts chemosensitivity in advanced gastric cancer BMC Cancer Gastric cancer Chemosensitivity Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Tumor differentiation |
author_facet |
Zhenhua Huang Yantan Liu Chen Yang Xiaoyin Li Changqie Pan Jinjun Rao Nailin Li Wangjun Liao Li Lin |
author_sort |
Zhenhua Huang |
title |
Combined neutrophil/platelet/lymphocyte/differentiation score predicts chemosensitivity in advanced gastric cancer |
title_short |
Combined neutrophil/platelet/lymphocyte/differentiation score predicts chemosensitivity in advanced gastric cancer |
title_full |
Combined neutrophil/platelet/lymphocyte/differentiation score predicts chemosensitivity in advanced gastric cancer |
title_fullStr |
Combined neutrophil/platelet/lymphocyte/differentiation score predicts chemosensitivity in advanced gastric cancer |
title_full_unstemmed |
Combined neutrophil/platelet/lymphocyte/differentiation score predicts chemosensitivity in advanced gastric cancer |
title_sort |
combined neutrophil/platelet/lymphocyte/differentiation score predicts chemosensitivity in advanced gastric cancer |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2018-05-01 |
description |
Abstract Background Gastric cancer is common in developing regions, and we hope to find out an economical but practical prognostic indicator. It was reported that pre-treatment peripheral neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), as well as differentiation status, were associated with cancer progression. Hence, we introduced a novel combined Neutrophil/platelet/lymphocyte/differentiation Score (cNPLDS) to improve the prediction value of palliative chemotherapeutic response in advanced gastric cancer. Methods According to statistical sample size estimation, 136 primary diagnosed unresectable advanced ptaients were included for a retrospective study. The follow-up end-point was progression free survival (PFS) during the first-line palliative chemotherapy. Differentiation stratified patients into well, medium and poor groups by score 1 to 3, while patients with neither elevated NLR and PLR, only one elevated, or both elevated were of the combined NLR-PLR score (cNPS) 1 to 3, respectively. The cNPLDS was calculated by multiplying the tumor differentiation score and cNPS. Results Determined by the receiver operating characteristic (ROC) curve, the optimal cut-off points for NLR and PLR were 3.04 and 223. Through univariate analysis and survival analysis, poor differentiation, high NLR, high PLR, high cNPS, and high cNPLDS respectively indicated inferior PFS during the first-line palliative chemotherapy. Patients were furhter classified into low to high risk groups by cNPLDS. Groups of elevated NLR, PLR, cNPS, and cNPLDS showed lower disease control rate. Compared to other parameters, cNPLDS significantly improved the accuracy in predicing the first-progression. Conclusions This study indicates that the novel parameter cNPLDS is superior to NLR or PLR alone, or even cNPS, in predicting the first-line chemosensitivity in advanced gastric cancer. |
topic |
Gastric cancer Chemosensitivity Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Tumor differentiation |
url |
http://link.springer.com/article/10.1186/s12885-018-4414-6 |
work_keys_str_mv |
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