Qualification and Application of a Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometric Method for the Determination of Adalimumab in Rat Plasma

Qualification and Application of a Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometric Method for the Determination of Adalimumab in Rat Plasma

A liquid chromatography–quadrupole time-of-flight (Q-TOF) mass spectrometric method was developed for early-stage research on adalimumab in rats. The method consisted of immunoprecipitation followed by tryptic digestion for sample preparation and LC-QTOF-MS/MS analysis of specific signatur...

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Bibliographic Details
Main Authors:	Yuri Park, Nahye Kim, Jangmi Choi, Min-Ho Park, Byeong ill Lee, Seok-Ho Shin, Jin-Ju Byeon, Young G. Shin
Format:	Article
Language:	English
Published:	MDPI AG 2018-05-01
Series:	Pharmaceutics
Subjects:	adalimumab immunoprecipitation liquid chromatography-quadrupole TOF MS bioanalysis
Online Access:	http://www.mdpi.com/1999-4923/10/2/61

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