ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable for cancer cells to grow in serine-limiting env...

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Bibliographic Details
Main Authors: Xingyao Li, Daniel Gracilla, Lun Cai, Mingyi Zhang, Xiaolin Yu, Xiaoguang Chen, Junran Zhang, Xiaochun Long, Han-Fei Ding, Chunhong Yan
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
ATF3
ATF4
serine biosynthesis
serine synthesis pathway
serine metabolism
serine deprivation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011530

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