Traditional used Plants against Cognitive Decline and Alzheimer Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized clinically by progressive memory deficits, impaired cognitive function, and altered and inappropriate behavior. Aging represents the most important risk factor for AD and the global trend in the phenomenon of population aging has...

Full description

Bibliographic Details
Main Author: Gunter Peter Eckert
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-12-01
Series:Frontiers in Pharmacology
Subjects:
TCM
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00138/full
id doaj-9c41b57a79bf4dd6a0a8b5b88f5357f4
record_format Article
spelling doaj-9c41b57a79bf4dd6a0a8b5b88f5357f42020-11-24T22:27:51ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122010-12-01110.3389/fphar.2010.001387753Traditional used Plants against Cognitive Decline and Alzheimer DiseaseGunter Peter Eckert0Goethe-UniversityAlzheimer’s disease (AD) is a neurodegenerative disorder characterized clinically by progressive memory deficits, impaired cognitive function, and altered and inappropriate behavior. Aging represents the most important risk factor for AD and the global trend in the phenomenon of population aging has dramatic consequences for public health, healthcare financing and delivery systems in the word and, especially in developing countries. Mounting evidence obtained in in vitro and in vivo studies, suggests that various traditionally used plants in Asia, India and Europe significantly affect key metabolic alterations culminating in AD-typical neurodegeneration. The present article aims to bring the reader up-to-date on the most recent studies and advances describing the direct and indirect activities of traditional used plants and its constituents possibly relieving features of AD. A variety of traditional used plants and its extracts exerted activities on AD related drug targets including AChE activity antioxidative activity, modulation of Aβ-producing secretase activities, Aβ-degradation, heavy metal chelating, induction of neurotrophic factors and cell death mechanisms. Although pre-clinical investigations identified promising drug candidates for AD, clinical evidences are still pending.http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00138/fullAlzheimerAyurvedaKampoTCMTraditional plantsTraditional use
collection DOAJ
language English
format Article
sources DOAJ
author Gunter Peter Eckert
spellingShingle Gunter Peter Eckert
Traditional used Plants against Cognitive Decline and Alzheimer Disease
Frontiers in Pharmacology
Alzheimer
Ayurveda
Kampo
TCM
Traditional plants
Traditional use
author_facet Gunter Peter Eckert
author_sort Gunter Peter Eckert
title Traditional used Plants against Cognitive Decline and Alzheimer Disease
title_short Traditional used Plants against Cognitive Decline and Alzheimer Disease
title_full Traditional used Plants against Cognitive Decline and Alzheimer Disease
title_fullStr Traditional used Plants against Cognitive Decline and Alzheimer Disease
title_full_unstemmed Traditional used Plants against Cognitive Decline and Alzheimer Disease
title_sort traditional used plants against cognitive decline and alzheimer disease
publisher Frontiers Media S.A.
series Frontiers in Pharmacology
issn 1663-9812
publishDate 2010-12-01
description Alzheimer’s disease (AD) is a neurodegenerative disorder characterized clinically by progressive memory deficits, impaired cognitive function, and altered and inappropriate behavior. Aging represents the most important risk factor for AD and the global trend in the phenomenon of population aging has dramatic consequences for public health, healthcare financing and delivery systems in the word and, especially in developing countries. Mounting evidence obtained in in vitro and in vivo studies, suggests that various traditionally used plants in Asia, India and Europe significantly affect key metabolic alterations culminating in AD-typical neurodegeneration. The present article aims to bring the reader up-to-date on the most recent studies and advances describing the direct and indirect activities of traditional used plants and its constituents possibly relieving features of AD. A variety of traditional used plants and its extracts exerted activities on AD related drug targets including AChE activity antioxidative activity, modulation of Aβ-producing secretase activities, Aβ-degradation, heavy metal chelating, induction of neurotrophic factors and cell death mechanisms. Although pre-clinical investigations identified promising drug candidates for AD, clinical evidences are still pending.
topic Alzheimer
Ayurveda
Kampo
TCM
Traditional plants
Traditional use
url http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00138/full
work_keys_str_mv AT gunterpetereckert traditionalusedplantsagainstcognitivedeclineandalzheimerdisease
_version_ 1725748786688425984