Model of binary biological mixture fractionation in gravity field and in centrifugal-force field

• Main Author: Andrzej Górka
• Format: Article
• Language: English
• Published: Wojskowa Akademia Techniczna, Redakcja Wydawnictw WAT, ul. gen. S. Kaliskiego 2, 00-908 Warszawa 2020-06-01
• Series: Biuletyn Wojskowej Akademii Technicznej
• Subjects: biological mixture fractionation; blood component sedimentation; mixture fractionation process model; peripheral blood ESR testing; fractionation in gravity field; fractionation in a centrifugal-force field
• Online Access: http://biuletynwat.pl/gicid/01.3001.0014.5633

The publication describes a simplified model of the process of fractionation of binary biological mixtures in a closed reference system. The description of the model uses a balance of masses and forces forcing microparticle movement in a base fluid matrix. The movement, consistent with the direction of the excitation forces, was limited to independent migration channels with diameters comparable to the diameters of the migrating microparticles. In this model, the parameters of the densification process of the separated fraction in a single migration channel were applied to the entire volume of the fractioned mixture. The developed model applies to theoretical bases of the erythrocyte sedimentation rate (ESR). Keywords: biological mixture fractionation, blood component sedimentation, mixture fractionation process model, peripheral blood ESR testing, fractionation in gravity field, fractionation in a centrifugal-force field