Relationship between Aging-Related Skin Dryness and Aquaporins
Skin function deteriorates with aging, and the dermal water content decreases. In this study, we have analyzed the mechanism of aging-related skin dryness focusing on aquaporins (AQPs), which are the water channels. Mice aged 3 and 20 months were designated as young and aged mice, respectively, to b...
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doaj-9c5f7d2cf67c419583d20f5bfaf7a8ba2020-11-25T00:17:03ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-07-01187155910.3390/ijms18071559ijms18071559Relationship between Aging-Related Skin Dryness and AquaporinsNobutomo Ikarashi0Risako Kon1Miho Kaneko2Nanaho Mizukami3Yoshiki Kusunoki4Kiyoshi Sugiyama5Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanGlobal Research Center for Innovative Life Science, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanSkin function deteriorates with aging, and the dermal water content decreases. In this study, we have analyzed the mechanism of aging-related skin dryness focusing on aquaporins (AQPs), which are the water channels. Mice aged 3 and 20 months were designated as young and aged mice, respectively, to be used in the experiments. No differences were observed in transepidermal water loss between the young mice and aged mice. However, the dermal water content in aged mice was significantly lower than that in young mice, thus showing skin dryness. The expression of AQP1, AQP3, AQP4, AQP7, and AQP9 was observed in the skin. All the mRNA expression levels of these AQPs were significantly lower in aged mice. For AQP3, which was expressed dominantly in the skin, the protein level was lower in aged mice than in young mice. The results of the study showed that the expression level of AQPs in the skin decreased with aging, suggesting the possibility that this was one of the causes of skin dryness. New targets for the prevention and treatment of aging-related skin dryness are expected to be proposed when the substance that increases the expression of AQP3 is found.https://www.mdpi.com/1422-0067/18/7/1559aquaporinskindermal water contentagedyoung |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nobutomo Ikarashi Risako Kon Miho Kaneko Nanaho Mizukami Yoshiki Kusunoki Kiyoshi Sugiyama |
spellingShingle |
Nobutomo Ikarashi Risako Kon Miho Kaneko Nanaho Mizukami Yoshiki Kusunoki Kiyoshi Sugiyama Relationship between Aging-Related Skin Dryness and Aquaporins International Journal of Molecular Sciences aquaporin skin dermal water content aged young |
author_facet |
Nobutomo Ikarashi Risako Kon Miho Kaneko Nanaho Mizukami Yoshiki Kusunoki Kiyoshi Sugiyama |
author_sort |
Nobutomo Ikarashi |
title |
Relationship between Aging-Related Skin Dryness and Aquaporins |
title_short |
Relationship between Aging-Related Skin Dryness and Aquaporins |
title_full |
Relationship between Aging-Related Skin Dryness and Aquaporins |
title_fullStr |
Relationship between Aging-Related Skin Dryness and Aquaporins |
title_full_unstemmed |
Relationship between Aging-Related Skin Dryness and Aquaporins |
title_sort |
relationship between aging-related skin dryness and aquaporins |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2017-07-01 |
description |
Skin function deteriorates with aging, and the dermal water content decreases. In this study, we have analyzed the mechanism of aging-related skin dryness focusing on aquaporins (AQPs), which are the water channels. Mice aged 3 and 20 months were designated as young and aged mice, respectively, to be used in the experiments. No differences were observed in transepidermal water loss between the young mice and aged mice. However, the dermal water content in aged mice was significantly lower than that in young mice, thus showing skin dryness. The expression of AQP1, AQP3, AQP4, AQP7, and AQP9 was observed in the skin. All the mRNA expression levels of these AQPs were significantly lower in aged mice. For AQP3, which was expressed dominantly in the skin, the protein level was lower in aged mice than in young mice. The results of the study showed that the expression level of AQPs in the skin decreased with aging, suggesting the possibility that this was one of the causes of skin dryness. New targets for the prevention and treatment of aging-related skin dryness are expected to be proposed when the substance that increases the expression of AQP3 is found. |
topic |
aquaporin skin dermal water content aged young |
url |
https://www.mdpi.com/1422-0067/18/7/1559 |
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