Quinacrine enhances temozolomide cytotoxicity in temozolomide-sensitive and -resistant glioblastoma cells
Background: The alkylating agent temozolomide (TMZ) is widely used in glioblastoma multiforme (GBM) therapy. Unfortunately, TMZ-resistance frequently occurs in recurrent GBM and is the major cause of treatment failure. The anti-malarial drug quinacrine (QC) harbors antitumor and chemosensitivity pro...
Main Authors: | Pingde Zhang, Ning Li, Karrie Mei Yee Kiang, Zhiyuan Zhu, Gloria Wai Man Leung, Stephen Yin Cheng, Gilberto Ka Kit Leung |
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Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2018-01-01
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Series: | Glioma |
Subjects: | |
Online Access: | http://www.jglioma.com/article.asp?issn=2589-6113;year=2018;volume=1;issue=5;spage=175;epage=181;aulast=Zhang |
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