Circ‐MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self‐Renewal of Hepatocellular Cancer Stem Cells

Circ‐MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self‐Renewal of Hepatocellular Cancer Stem Cells

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Abstract Both circular RNAs (circRNAs) and cancer stem cells (CSCs) are separately known to be involved in cancer, but their interaction remains unclear. Here, the regulation of hepatocellular CSC self‐renewal is discovered by a circRNA, circ‐MALAT1, which is produced by back‐splicing of a long nonc...

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Bibliographic Details
Main Authors: Liang Chen, Ruijiao Kong, Cong Wu, Shuo Wang, Zixin Liu, Shupeng Liu, Shuiping Li, Tian Chen, Chuanbin Mao, Shanrong Liu
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Advanced Science
Subjects:
circular RNA
hepatocellular cancer stem cells
miR‐6887‐3p
PAX5
ribosomes
self‐renewal
Online Access:https://doi.org/10.1002/advs.201900949

Internet

https://doi.org/10.1002/advs.201900949

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