SALM4 negatively regulates NMDA receptor function and fear memory consolidation

SALM4 negatively regulates NMDA receptor function and fear memory consolidation

To elucidate the role of synaptic cell adhesion-like molecule 4 (SALM4) in altering synaptic function in the context of fear memory, Lie at al performed behavioural and electrophysiological assessments of SALM4 knockout mice undergoing cued fear, spatial, and object-recognition memory tasks. They de...

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Main Authors: Eunkyung Lie, Yeji Yeo, Eun-Jae Lee, Wangyong Shin, Kyungdeok Kim, Kyung Ah Han, Esther Yang, Tae-Yong Choi, Mihyun Bae, Suho Lee, Seung Min Um, Se-Young Choi, Hyun Kim, Jaewon Ko, Eunjoon Kim
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02656-3
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spelling doaj-9c6821f43b5b415bb8a595e34ac8759f2021-10-03T11:15:33ZengNature Publishing GroupCommunications Biology2399-36422021-09-014111710.1038/s42003-021-02656-3SALM4 negatively regulates NMDA receptor function and fear memory consolidationEunkyung Lie0Yeji Yeo1Eun-Jae Lee2Wangyong Shin3Kyungdeok Kim4Kyung Ah Han5Esther Yang6Tae-Yong Choi7Mihyun Bae8Suho Lee9Seung Min Um10Se-Young Choi11Hyun Kim12Jaewon Ko13Eunjoon Kim14Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)Department of Neurology, Asan Medical Center, University of Ulsan, College of MedicineCenter for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST)Department of Anatomy and Division of Brain Korea 21, Biomedical Science, College of Medicine, Korea UniversityDepartment of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of DentistryCenter for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of DentistryDepartment of Anatomy and Division of Brain Korea 21, Biomedical Science, College of Medicine, Korea UniversityDepartment of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST)Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)To elucidate the role of synaptic cell adhesion-like molecule 4 (SALM4) in altering synaptic function in the context of fear memory, Lie at al performed behavioural and electrophysiological assessments of SALM4 knockout mice undergoing cued fear, spatial, and object-recognition memory tasks. They demonstrated that SALM4 suppresses heightened GluN2B-expressing NMDA receptor function specifically during fear memory consolidation.https://doi.org/10.1038/s42003-021-02656-3
collection DOAJ
language English
format Article
sources DOAJ
author Eunkyung Lie
Yeji Yeo
Eun-Jae Lee
Wangyong Shin
Kyungdeok Kim
Kyung Ah Han
Esther Yang
Tae-Yong Choi
Mihyun Bae
Suho Lee
Seung Min Um
Se-Young Choi
Hyun Kim
Jaewon Ko
Eunjoon Kim
spellingShingle Eunkyung Lie
Yeji Yeo
Eun-Jae Lee
Wangyong Shin
Kyungdeok Kim
Kyung Ah Han
Esther Yang
Tae-Yong Choi
Mihyun Bae
Suho Lee
Seung Min Um
Se-Young Choi
Hyun Kim
Jaewon Ko
Eunjoon Kim
SALM4 negatively regulates NMDA receptor function and fear memory consolidation
Communications Biology
author_facet Eunkyung Lie
Yeji Yeo
Eun-Jae Lee
Wangyong Shin
Kyungdeok Kim
Kyung Ah Han
Esther Yang
Tae-Yong Choi
Mihyun Bae
Suho Lee
Seung Min Um
Se-Young Choi
Hyun Kim
Jaewon Ko
Eunjoon Kim
author_sort Eunkyung Lie
title SALM4 negatively regulates NMDA receptor function and fear memory consolidation
title_short SALM4 negatively regulates NMDA receptor function and fear memory consolidation
title_full SALM4 negatively regulates NMDA receptor function and fear memory consolidation
title_fullStr SALM4 negatively regulates NMDA receptor function and fear memory consolidation
title_full_unstemmed SALM4 negatively regulates NMDA receptor function and fear memory consolidation
title_sort salm4 negatively regulates nmda receptor function and fear memory consolidation
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-09-01
description To elucidate the role of synaptic cell adhesion-like molecule 4 (SALM4) in altering synaptic function in the context of fear memory, Lie at al performed behavioural and electrophysiological assessments of SALM4 knockout mice undergoing cued fear, spatial, and object-recognition memory tasks. They demonstrated that SALM4 suppresses heightened GluN2B-expressing NMDA receptor function specifically during fear memory consolidation.
url https://doi.org/10.1038/s42003-021-02656-3
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