A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging
Nanoparticles (NPs) have been used as contrast agents for several bioimaging modalities. X-ray fluorescence (XRF) tomography can provide sensitive and quantitative 3D detection of NPs. With spectrally matched NPs as contrast agents, we demonstrated earlier in a laboratory system that XRF tomography...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi-Wiley
2018-01-01
|
Series: | Contrast Media & Molecular Imaging |
Online Access: | http://dx.doi.org/10.1155/2018/8174820 |
id |
doaj-9c6891b9ee9b4bc99c7cd0c6c3afe0d6 |
---|---|
record_format |
Article |
spelling |
doaj-9c6891b9ee9b4bc99c7cd0c6c3afe0d62020-11-25T00:36:26ZengHindawi-WileyContrast Media & Molecular Imaging1555-43091555-43172018-01-01201810.1155/2018/81748208174820A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography BioimagingYuyang Li0Kian Shaker1Jakob C. Larsson2Carmen Vogt3Hans M. Hertz4Muhammet S. Toprak5Department of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology/Albanova, SE 106 91 Stockholm, SwedenDepartment of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology/Albanova, SE 106 91 Stockholm, SwedenDepartment of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology/Albanova, SE 106 91 Stockholm, SwedenDepartment of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology/Albanova, SE 106 91 Stockholm, SwedenDepartment of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology/Albanova, SE 106 91 Stockholm, SwedenDepartment of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology/Albanova, SE 106 91 Stockholm, SwedenNanoparticles (NPs) have been used as contrast agents for several bioimaging modalities. X-ray fluorescence (XRF) tomography can provide sensitive and quantitative 3D detection of NPs. With spectrally matched NPs as contrast agents, we demonstrated earlier in a laboratory system that XRF tomography could achieve high-spatial-resolution tumor imaging in mice. Here, we present the synthesis, characterization, and evaluation of a library of NPs containing Y, Zr, Nb, Rh, and Ru that have spectrally matched K-shell absorption for the laboratory scale X-ray source. The K-shell emissions of these NPs are spectrally well separated from the X-ray probe and the Compton background, making them suitable for the lab-scale XRF tomography system. Their potential as XRF contrast agents is demonstrated successfully in a small-animal equivalent phantom, confirming the simulation results. The diversity in the NP composition provides a flexible platform for a better design and biological optimization of XRF tomography nanoprobes.http://dx.doi.org/10.1155/2018/8174820 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuyang Li Kian Shaker Jakob C. Larsson Carmen Vogt Hans M. Hertz Muhammet S. Toprak |
spellingShingle |
Yuyang Li Kian Shaker Jakob C. Larsson Carmen Vogt Hans M. Hertz Muhammet S. Toprak A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging Contrast Media & Molecular Imaging |
author_facet |
Yuyang Li Kian Shaker Jakob C. Larsson Carmen Vogt Hans M. Hertz Muhammet S. Toprak |
author_sort |
Yuyang Li |
title |
A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging |
title_short |
A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging |
title_full |
A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging |
title_fullStr |
A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging |
title_full_unstemmed |
A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging |
title_sort |
library of potential nanoparticle contrast agents for x-ray fluorescence tomography bioimaging |
publisher |
Hindawi-Wiley |
series |
Contrast Media & Molecular Imaging |
issn |
1555-4309 1555-4317 |
publishDate |
2018-01-01 |
description |
Nanoparticles (NPs) have been used as contrast agents for several bioimaging modalities. X-ray fluorescence (XRF) tomography can provide sensitive and quantitative 3D detection of NPs. With spectrally matched NPs as contrast agents, we demonstrated earlier in a laboratory system that XRF tomography could achieve high-spatial-resolution tumor imaging in mice. Here, we present the synthesis, characterization, and evaluation of a library of NPs containing Y, Zr, Nb, Rh, and Ru that have spectrally matched K-shell absorption for the laboratory scale X-ray source. The K-shell emissions of these NPs are spectrally well separated from the X-ray probe and the Compton background, making them suitable for the lab-scale XRF tomography system. Their potential as XRF contrast agents is demonstrated successfully in a small-animal equivalent phantom, confirming the simulation results. The diversity in the NP composition provides a flexible platform for a better design and biological optimization of XRF tomography nanoprobes. |
url |
http://dx.doi.org/10.1155/2018/8174820 |
work_keys_str_mv |
AT yuyangli alibraryofpotentialnanoparticlecontrastagentsforxrayfluorescencetomographybioimaging AT kianshaker alibraryofpotentialnanoparticlecontrastagentsforxrayfluorescencetomographybioimaging AT jakobclarsson alibraryofpotentialnanoparticlecontrastagentsforxrayfluorescencetomographybioimaging AT carmenvogt alibraryofpotentialnanoparticlecontrastagentsforxrayfluorescencetomographybioimaging AT hansmhertz alibraryofpotentialnanoparticlecontrastagentsforxrayfluorescencetomographybioimaging AT muhammetstoprak alibraryofpotentialnanoparticlecontrastagentsforxrayfluorescencetomographybioimaging AT yuyangli libraryofpotentialnanoparticlecontrastagentsforxrayfluorescencetomographybioimaging AT kianshaker libraryofpotentialnanoparticlecontrastagentsforxrayfluorescencetomographybioimaging AT jakobclarsson libraryofpotentialnanoparticlecontrastagentsforxrayfluorescencetomographybioimaging AT carmenvogt libraryofpotentialnanoparticlecontrastagentsforxrayfluorescencetomographybioimaging AT hansmhertz libraryofpotentialnanoparticlecontrastagentsforxrayfluorescencetomographybioimaging AT muhammetstoprak libraryofpotentialnanoparticlecontrastagentsforxrayfluorescencetomographybioimaging |
_version_ |
1725305352136687616 |