Tg2576 cortical neurons that express human Ab are susceptible to extracellular Aβ-induced, K+ efflux dependent neurodegeneration.
<h4>Background</h4>One of the key pathological features of AD is the formation of insoluble amyloid plaques. The major constituent of these extracellular plaques is the beta-amyloid peptide (Aβ), although Aβ is also found to accumulate intraneuronally in AD. Due to the slowly progressive...
Main Authors: | Shannon Ray, Claire Howells, Emma D Eaton, Chris W Butler, Lana Shabala, Paul A Adlard, Adrian K West, William R Bennett, Gilles J Guillemin, Roger S Chung |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-04-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21556141/pdf/?tool=EBI |
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