Negatively charged phospholipids stimulate factor XI activation by thrombin
Introduction: Coagulation factor XI (FXI) is the zymogen of the serine-protease FXIa, which contributes to thrombin formation by activating factor IX. FXI can be activated by factor XIIa or thrombin, but thrombin-catalysed FXI activation is highly inefficient, unless stimulated by polyanions such as...
Main Authors: | Farida Omarova, Jan Rosing, Rogier M. Bertina, Elisabetta Castoldi |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
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Series: | Thrombosis Update |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2666572720300225 |
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