Role of Phagocytosis in the Pro-Inflammatory Response in LDL-Induced Foam Cell Formation; a Transcriptome Analysis

Role of Phagocytosis in the Pro-Inflammatory Response in LDL-Induced Foam Cell Formation; a Transcriptome Analysis

Excessive accumulation of lipid inclusions in the arterial wall cells (foam cell formation) caused by modified low-density lipoprotein (LDL) is the earliest and most noticeable manifestation of atherosclerosis. The mechanisms of foam cell formation are not fully understood and can involve altered li...

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Main Authors: Alexander N. Orekhov, Nikita G. Nikiforov, Vasily N. Sukhorukov, Marina V. Kubekina, Igor A. Sobenin, Wei-Kai Wu, Kathy K. Foxx, Sergey Pintus, Philip Stegmaier, Daria Stelmashenko, Alexander Kel, Alexei N. Gratchev, Alexandra A. Melnichenko, Reinhard Wetzker, Volha I. Summerhill, Ichiro Manabe, Yumiko Oishi
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
atherosclerosis
transcriptome
lipoprotein
phagocytosis
innate immunity
Online Access:https://www.mdpi.com/1422-0067/21/3/817

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