Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History
Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes,...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Golestan University Of Medical Sciences
2018-12-01
|
Series: | Journal of Clinical and Basic Research |
Subjects: | |
Online Access: | http://jcbr.goums.ac.ir/article-1-168-en.html |
id |
doaj-9c70c0e8541a4b1896da366b607f03a2 |
---|---|
record_format |
Article |
spelling |
doaj-9c70c0e8541a4b1896da366b607f03a22020-11-25T01:15:06ZengGolestan University Of Medical SciencesJournal of Clinical and Basic Research2538-37362018-12-01244853Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family HistoryHalime Rahimnia0Abdolvahab Moradi1Naemeh Javid2Yasaman Fateri3Shabbou Bahramian4Zahra Roohinejad5Hossein Sabouri6Eisa Jorjani7 Department of Biology, Gonbad Kavous University, Gonbad Kavous, Iran Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran Department of Biology, Gonbad Kavous University, Gonbad Kavous, Iran Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran *Correspondence: Eisa Jorjani, Department of Biology, Gonbad Kavous Univers Department of Biology, Gonbad Kavous University, Gonbad Kavous, Iran Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC. Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls. Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02). Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding.http://jcbr.goums.ac.ir/article-1-168-en.htmlesophageal cancerescclncrnalnc-pou3f3 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Halime Rahimnia Abdolvahab Moradi Naemeh Javid Yasaman Fateri Shabbou Bahramian Zahra Roohinejad Hossein Sabouri Eisa Jorjani |
spellingShingle |
Halime Rahimnia Abdolvahab Moradi Naemeh Javid Yasaman Fateri Shabbou Bahramian Zahra Roohinejad Hossein Sabouri Eisa Jorjani Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History Journal of Clinical and Basic Research esophageal cancer escc lncrna lnc-pou3f3 |
author_facet |
Halime Rahimnia Abdolvahab Moradi Naemeh Javid Yasaman Fateri Shabbou Bahramian Zahra Roohinejad Hossein Sabouri Eisa Jorjani |
author_sort |
Halime Rahimnia |
title |
Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History |
title_short |
Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History |
title_full |
Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History |
title_fullStr |
Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History |
title_full_unstemmed |
Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History |
title_sort |
overexpression of long non-coding rna pou3f3 in esophageal squamous cell carcinoma is associated with tnm stage and family history |
publisher |
Golestan University Of Medical Sciences |
series |
Journal of Clinical and Basic Research |
issn |
2538-3736 |
publishDate |
2018-12-01 |
description |
Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC.
Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls.
Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02).
Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding. |
topic |
esophageal cancer escc lncrna lnc-pou3f3 |
url |
http://jcbr.goums.ac.ir/article-1-168-en.html |
work_keys_str_mv |
AT halimerahimnia overexpressionoflongnoncodingrnapou3f3inesophagealsquamouscellcarcinomaisassociatedwithtnmstageandfamilyhistory AT abdolvahabmoradi overexpressionoflongnoncodingrnapou3f3inesophagealsquamouscellcarcinomaisassociatedwithtnmstageandfamilyhistory AT naemehjavid overexpressionoflongnoncodingrnapou3f3inesophagealsquamouscellcarcinomaisassociatedwithtnmstageandfamilyhistory AT yasamanfateri overexpressionoflongnoncodingrnapou3f3inesophagealsquamouscellcarcinomaisassociatedwithtnmstageandfamilyhistory AT shabboubahramian overexpressionoflongnoncodingrnapou3f3inesophagealsquamouscellcarcinomaisassociatedwithtnmstageandfamilyhistory AT zahraroohinejad overexpressionoflongnoncodingrnapou3f3inesophagealsquamouscellcarcinomaisassociatedwithtnmstageandfamilyhistory AT hosseinsabouri overexpressionoflongnoncodingrnapou3f3inesophagealsquamouscellcarcinomaisassociatedwithtnmstageandfamilyhistory AT eisajorjani overexpressionoflongnoncodingrnapou3f3inesophagealsquamouscellcarcinomaisassociatedwithtnmstageandfamilyhistory |
_version_ |
1725154435866296320 |