Determination of related substances in lisinopril and amlodipine tablets by HPLC
Objective: To establish an HPLC method for determining the related substances in lisinopril and amlodipine tablets. Methods: An Inertsil Thermo BDS HYPERSIL C18 (4.6 mm伊250 mm, 5 μm) column was used with the Acetonitrile-water-phosphoric acid (10:90:0.1) as mobile phase A and Acetonitrile-water-ph...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2016-06-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201611/3.pdf |
| Summary: | Objective: To establish an HPLC method for determining the related substances in lisinopril
and amlodipine tablets. Methods: An Inertsil Thermo BDS HYPERSIL C18 (4.6 mm伊250 mm, 5 μm) column was used with the Acetonitrile-water-phosphoric acid (10:90:0.1)
as mobile phase A and Acetonitrile-water-phosphoric acid (90:10:0.1) as mobile phase B by
gradient elution at the detection wavelength of 215 nm. The flow rate was 1.0 mL/min and the
column temperature was 30 ℃. Results: The separation of the impurity peak and peak was
good. Besides, all the impurities could be detected effectively. Conclusions: The method is
sensitive, accurate and selective. It is suitable for control the related substances in lisinopril and
Amlodipine tablets.
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| ISSN: | 1007-1237 1007-1237 |