The role of the human gut microbiota in colonization and infection with multidrug-resistant bacteria
About 100 years ago, the first antibiotic drug was introduced into health care. Since then, antibiotics have made an outstanding impact on human medicine. However, our society increasingly suffers from collateral damage exerted by these highly effective drugs. The rise of resistant pathogen strains,...
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2021-01-01
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Online Access: | http://dx.doi.org/10.1080/19490976.2021.1911279 |
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doaj-9c79834a9b1e48ea99b46744765df0f22021-07-06T12:16:09ZengTaylor & Francis GroupGut Microbes1949-09761949-09842021-01-0113110.1080/19490976.2021.19112791911279The role of the human gut microbiota in colonization and infection with multidrug-resistant bacteriaIrene Wuethrich0Benedikt W. Pelzer1Yascha Khodamoradi2Maria J. G. T. Vehreschild3ETH ZurichUniversity of CologneUniversity Hospital Frankfurt, Goethe University FrankfurtUniversity Hospital Frankfurt, Goethe University FrankfurtAbout 100 years ago, the first antibiotic drug was introduced into health care. Since then, antibiotics have made an outstanding impact on human medicine. However, our society increasingly suffers from collateral damage exerted by these highly effective drugs. The rise of resistant pathogen strains, combined with a reduction of microbiota diversity upon antibiotic treatment, has become a significant obstacle in the fight against invasive infections worldwide. Alternative and complementary strategies to classical “Fleming antibiotics” comprise microbiota-based treatments such as fecal microbiota transfer and administration of probiotics, live-biotherapeutics, prebiotics, and postbiotics. Other promising interventions, whose efficacy may also be influenced by the human microbiota, are phages and vaccines. They will facilitate antimicrobial stewardship, to date the only globally applied antibiotic resistance mitigation strategy. In this review, we present the available evidence on these nontraditional interventions, highlight their interaction with the human microbiota, and discuss their clinical applicability.http://dx.doi.org/10.1080/19490976.2021.1911279microbiotamultidrug resistancebacterial infectiondysbiosismicrobial therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Irene Wuethrich Benedikt W. Pelzer Yascha Khodamoradi Maria J. G. T. Vehreschild |
spellingShingle |
Irene Wuethrich Benedikt W. Pelzer Yascha Khodamoradi Maria J. G. T. Vehreschild The role of the human gut microbiota in colonization and infection with multidrug-resistant bacteria Gut Microbes microbiota multidrug resistance bacterial infection dysbiosis microbial therapy |
author_facet |
Irene Wuethrich Benedikt W. Pelzer Yascha Khodamoradi Maria J. G. T. Vehreschild |
author_sort |
Irene Wuethrich |
title |
The role of the human gut microbiota in colonization and infection with multidrug-resistant bacteria |
title_short |
The role of the human gut microbiota in colonization and infection with multidrug-resistant bacteria |
title_full |
The role of the human gut microbiota in colonization and infection with multidrug-resistant bacteria |
title_fullStr |
The role of the human gut microbiota in colonization and infection with multidrug-resistant bacteria |
title_full_unstemmed |
The role of the human gut microbiota in colonization and infection with multidrug-resistant bacteria |
title_sort |
role of the human gut microbiota in colonization and infection with multidrug-resistant bacteria |
publisher |
Taylor & Francis Group |
series |
Gut Microbes |
issn |
1949-0976 1949-0984 |
publishDate |
2021-01-01 |
description |
About 100 years ago, the first antibiotic drug was introduced into health care. Since then, antibiotics have made an outstanding impact on human medicine. However, our society increasingly suffers from collateral damage exerted by these highly effective drugs. The rise of resistant pathogen strains, combined with a reduction of microbiota diversity upon antibiotic treatment, has become a significant obstacle in the fight against invasive infections worldwide. Alternative and complementary strategies to classical “Fleming antibiotics” comprise microbiota-based treatments such as fecal microbiota transfer and administration of probiotics, live-biotherapeutics, prebiotics, and postbiotics. Other promising interventions, whose efficacy may also be influenced by the human microbiota, are phages and vaccines. They will facilitate antimicrobial stewardship, to date the only globally applied antibiotic resistance mitigation strategy. In this review, we present the available evidence on these nontraditional interventions, highlight their interaction with the human microbiota, and discuss their clinical applicability. |
topic |
microbiota multidrug resistance bacterial infection dysbiosis microbial therapy |
url |
http://dx.doi.org/10.1080/19490976.2021.1911279 |
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