Suitability of Pedigree Information and Genomic Methods for Analyzing Inbreeding of Polish Cold-Blooded Horses Covered by Conservation Programs
Traditionally, pedigree-based relationship coefficients were used to manage inbreeding and control inbreeding depression that occurs within populations. The extensive incorporation of genomic data in livestock breeding creates the opportunity to develop and implement methods to manage populations at...
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doaj-9c8430e6891d49b4bfab7119ec5dc6472021-03-18T00:03:26ZengMDPI AGGenes2073-44252021-03-011242942910.3390/genes12030429Suitability of Pedigree Information and Genomic Methods for Analyzing Inbreeding of Polish Cold-Blooded Horses Covered by Conservation ProgramsGrażyna Polak0Artur Gurgul1Igor Jasielczuk2Tomasz Szmatoła3Jędrzej Krupiński4Monika Bugno-Poniewierska5Department of Horse Breeding, National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, PolandCenter for Experimental and Innovative Medicine, University of Agriculture in Krakow, Rędzina 1c, 30-248 Kraków, PolandCenter for Experimental and Innovative Medicine, University of Agriculture in Krakow, Rędzina 1c, 30-248 Kraków, PolandCenter for Experimental and Innovative Medicine, University of Agriculture in Krakow, Rędzina 1c, 30-248 Kraków, PolandDepartment of Horse Breeding, National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, PolandDepartment of Animal Reproduction, Anatomy and Genomics, University of Agriculture in Kraków, al. Mickiewicza 24/28, 30-059 Kraków, PolandTraditionally, pedigree-based relationship coefficients were used to manage inbreeding and control inbreeding depression that occurs within populations. The extensive incorporation of genomic data in livestock breeding creates the opportunity to develop and implement methods to manage populations at the genomic level. Consequently, the realized proportion of the genome that two individuals share can be more accurately estimated instead of using pedigree information to estimate the expected proportion of shared alleles. To make use of this improvement, in this study we evaluated the genomic inbreeding measures in the Polish conserved cold-blooded horse population and compared the data with the traditional measures of inbreeding. Additionally, an ancestry fractions/proportions from Admixture software were tested as an estimate of lineage (ancestry coefficient) used for horses qualifying for the conservation program. The highest correlation of pedigree-based (F<sub>PED</sub>) and genomic inbreeding estimates was found for F<sub>ROH</sub> (runs of homozygosity-based F coefficient) and F<sub>UNI</sub> (F coefficient based on the correlation between uniting gametes). F<sub>ROH</sub> correlation with F<sub>PED</sub> tended to increase as the number of generations registered as pedigree increased. While lineage and gene contributions (Q) from Admixture software correlated, they showed poor direct compliance; hence, Q-value cannot be recommended as the estimate of pedigree-based lineage. All these findings suggest that the methods of genomics should be considered as an alternative or support in the analysis of population structure in conservative breeding that can help control inbreeding in rare horse populations.https://www.mdpi.com/2073-4425/12/3/429horseinbreedingSNPgenomicpedigree |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Grażyna Polak Artur Gurgul Igor Jasielczuk Tomasz Szmatoła Jędrzej Krupiński Monika Bugno-Poniewierska |
spellingShingle |
Grażyna Polak Artur Gurgul Igor Jasielczuk Tomasz Szmatoła Jędrzej Krupiński Monika Bugno-Poniewierska Suitability of Pedigree Information and Genomic Methods for Analyzing Inbreeding of Polish Cold-Blooded Horses Covered by Conservation Programs Genes horse inbreeding SNP genomic pedigree |
author_facet |
Grażyna Polak Artur Gurgul Igor Jasielczuk Tomasz Szmatoła Jędrzej Krupiński Monika Bugno-Poniewierska |
author_sort |
Grażyna Polak |
title |
Suitability of Pedigree Information and Genomic Methods for Analyzing Inbreeding of Polish Cold-Blooded Horses Covered by Conservation Programs |
title_short |
Suitability of Pedigree Information and Genomic Methods for Analyzing Inbreeding of Polish Cold-Blooded Horses Covered by Conservation Programs |
title_full |
Suitability of Pedigree Information and Genomic Methods for Analyzing Inbreeding of Polish Cold-Blooded Horses Covered by Conservation Programs |
title_fullStr |
Suitability of Pedigree Information and Genomic Methods for Analyzing Inbreeding of Polish Cold-Blooded Horses Covered by Conservation Programs |
title_full_unstemmed |
Suitability of Pedigree Information and Genomic Methods for Analyzing Inbreeding of Polish Cold-Blooded Horses Covered by Conservation Programs |
title_sort |
suitability of pedigree information and genomic methods for analyzing inbreeding of polish cold-blooded horses covered by conservation programs |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2021-03-01 |
description |
Traditionally, pedigree-based relationship coefficients were used to manage inbreeding and control inbreeding depression that occurs within populations. The extensive incorporation of genomic data in livestock breeding creates the opportunity to develop and implement methods to manage populations at the genomic level. Consequently, the realized proportion of the genome that two individuals share can be more accurately estimated instead of using pedigree information to estimate the expected proportion of shared alleles. To make use of this improvement, in this study we evaluated the genomic inbreeding measures in the Polish conserved cold-blooded horse population and compared the data with the traditional measures of inbreeding. Additionally, an ancestry fractions/proportions from Admixture software were tested as an estimate of lineage (ancestry coefficient) used for horses qualifying for the conservation program. The highest correlation of pedigree-based (F<sub>PED</sub>) and genomic inbreeding estimates was found for F<sub>ROH</sub> (runs of homozygosity-based F coefficient) and F<sub>UNI</sub> (F coefficient based on the correlation between uniting gametes). F<sub>ROH</sub> correlation with F<sub>PED</sub> tended to increase as the number of generations registered as pedigree increased. While lineage and gene contributions (Q) from Admixture software correlated, they showed poor direct compliance; hence, Q-value cannot be recommended as the estimate of pedigree-based lineage. All these findings suggest that the methods of genomics should be considered as an alternative or support in the analysis of population structure in conservative breeding that can help control inbreeding in rare horse populations. |
topic |
horse inbreeding SNP genomic pedigree |
url |
https://www.mdpi.com/2073-4425/12/3/429 |
work_keys_str_mv |
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