Self-organization of blood pressure regulation: Clinical evidence

• Main Authors: Jacques-Olivier eFortrat, claude egharib
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2016-03-01
• Series: Frontiers in Physiology
• Subjects: Autonomic Nervous System; Baroreflex; Syncope; self-organized criticality; non-linear dynamics; blood pressure control
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00113/full

The pathogenesis of vasovagal syncope has remained elusive despite many efforts to identify an underlying dysfunction. Catastrophe theory explains the spontaneous occurrence of sudden events in some mathematically complex systems known as self-organized systems poised at criticality. These systems universally exhibit a power law initially described in earthquake occurrence: the Gutenberg Richter law. The magnitude plotted against the total number of earthquakes of at least this magnitude draw a straight line on log-log graph. We hypothesized that vasovagal syncope is a catastrophe occurring spontaneously in the cardiovascular system. We counted the number and magnitude (number of beats) of vasovagal reactions (simultaneous decreases in both blood pressure and heart rate on consecutive beats) in 24 patients with vasovagal symptoms during a head-up tilt test and 24 paired patients with no symptoms during the test. For each patient, we checked whether vasovagal reaction occurrence followed the Gutenberg Richter law. The occurrence followed the Gutenberg Richter law in 43 patients (correlation coefficient |r| = 0.986  0.001, mean  SEM) out of 48, with no difference between patients with and without symptoms. We demonstrated that vasovagal syncope matches a catastrophe model occurring in a self-organized cardiovascular complex system poised at criticality. This is a new vision of cardiovascular regulation and its related disorders.