RESULTS OF EXPERIMENTAL STUDIES OF THE CHILDREN’S AXIAL PUMP «DON-3»

• Main Authors: G. P. Itkin, O. Yu. Dmitrieva, A. S. Buchnev, A. A. Drobyshev, A. P. Kuleshov, A. V. Volkova, T. A. Halilulin
• Format: Article
• Language: Russian
• Published: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 2018-06-01
• Series: Vestnik Transplantologii i Iskusstvennyh Organov
• Subjects: mechanical support of blood circulation; pumps of non-pulsating fl ow; children’s axial pump; terminal heart failure
• Online Access: https://journal.transpl.ru/vtio/article/view/883

Aim. To evaluate the functioning of an implantable pediatric axial pump «DON-3» for bypassing the left ventricle of the heart in experiments on sheep.Materials and methods. Five sheeps at the age of 12–18 months performed paracorporeal installation of the children’s axial pump «DON-3» according to the scheme «left ventricle – aorta».Results. A technique was developed and 5 chronic experiments were conducted on sheep to assess the model of the children’s axial pump «DON-3». The duration of the experiments in this series averaged 9 ± 5 days. The main indicators of hemodynamics, acid-base balance were within the norm. Conducted morphological and histological studies of the kidneys, liver and lungs did not reveal the presence of zones of ischemia and thromboembolism.Conclusion. The results of this series of experiments showed satisfactory results, suggesting further research on the development of prototypes of a pediatric pump for clinical practice.