ICSI versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility: A Retrospective Evaluation of 685 Cycles with Propensity Score Model
This study compared the cumulative live birth rates following Intracytoplasmic sperm injection (ICSI) versus conventional in vitro fertilization (cIVF) in women aged 40 years or more and unexplained infertility. A cohort of 685 women undergoing either autologous conventional IVF or ICSI was retrospe...
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doaj-9c9b0ef5d60445de808d78a3a814f0ae2020-11-25T00:46:04ZengMDPI AGJournal of Clinical Medicine2077-03832019-10-01810169410.3390/jcm8101694jcm8101694ICSI versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility: A Retrospective Evaluation of 685 Cycles with Propensity Score ModelGianluca Gennarelli0Andrea Carosso1Stefano Canosa2Claudia Filippini3Sara Cesarano4Carlotta Scarafia5Nicole Brunod6Alberto Revelli7Chiara Benedetto8Obstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant’Anna Hospital, University of Torino, 10042 Torino, ItalyObstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant’Anna Hospital, University of Torino, 10042 Torino, ItalyObstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant’Anna Hospital, University of Torino, 10042 Torino, ItalyDepartment of Surgical Sciences, University of Torino, 10042 Torino, ItalyObstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant’Anna Hospital, University of Torino, 10042 Torino, ItalyObstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant’Anna Hospital, University of Torino, 10042 Torino, ItalyObstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant’Anna Hospital, University of Torino, 10042 Torino, ItalyObstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant’Anna Hospital, University of Torino, 10042 Torino, ItalyObstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant’Anna Hospital, University of Torino, 10042 Torino, ItalyThis study compared the cumulative live birth rates following Intracytoplasmic sperm injection (ICSI) versus conventional in vitro fertilization (cIVF) in women aged 40 years or more and unexplained infertility. A cohort of 685 women undergoing either autologous conventional IVF or ICSI was retrospectively analyzed. The effects of conventional IVF or ICSI procedure on cumulative pregnancy and live birth rates were evaluated in univariate and in multivariable analysis. In order to reduce potential differences between women undergoing either IVF or ICSI and to obtain unbiased estimation of the treatment effect, propensity score was estimated. ICSI was performed in 307 couples (ICSI group), whereas cIVF was performed in 297 couples (cIVF group), resulting in 45 and 43 live deliveries, respectively. No differences were observed in morphological embryo quality, in the number of cleavage stage embryos, in the number of transferred embryos, and in the number of vitrified embryos. As for the clinical outcome, no differences were observed in pregnancy rate, cumulative pregnancy rate, live birth rate, cumulative live birth rate, and abortion rate. The present results suggest that ICSI is not associated with increased likelihood of a live birth for unexplained, non-male factor infertility, in women aged 40 years or more.https://www.mdpi.com/2077-0383/8/10/1694in vitro fertilizationicsiivfnon-male factor infertilitycumulative live birth rates |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gianluca Gennarelli Andrea Carosso Stefano Canosa Claudia Filippini Sara Cesarano Carlotta Scarafia Nicole Brunod Alberto Revelli Chiara Benedetto |
spellingShingle |
Gianluca Gennarelli Andrea Carosso Stefano Canosa Claudia Filippini Sara Cesarano Carlotta Scarafia Nicole Brunod Alberto Revelli Chiara Benedetto ICSI versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility: A Retrospective Evaluation of 685 Cycles with Propensity Score Model Journal of Clinical Medicine in vitro fertilization icsi ivf non-male factor infertility cumulative live birth rates |
author_facet |
Gianluca Gennarelli Andrea Carosso Stefano Canosa Claudia Filippini Sara Cesarano Carlotta Scarafia Nicole Brunod Alberto Revelli Chiara Benedetto |
author_sort |
Gianluca Gennarelli |
title |
ICSI versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility: A Retrospective Evaluation of 685 Cycles with Propensity Score Model |
title_short |
ICSI versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility: A Retrospective Evaluation of 685 Cycles with Propensity Score Model |
title_full |
ICSI versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility: A Retrospective Evaluation of 685 Cycles with Propensity Score Model |
title_fullStr |
ICSI versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility: A Retrospective Evaluation of 685 Cycles with Propensity Score Model |
title_full_unstemmed |
ICSI versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility: A Retrospective Evaluation of 685 Cycles with Propensity Score Model |
title_sort |
icsi versus conventional ivf in women aged 40 years or more and unexplained infertility: a retrospective evaluation of 685 cycles with propensity score model |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-10-01 |
description |
This study compared the cumulative live birth rates following Intracytoplasmic sperm injection (ICSI) versus conventional in vitro fertilization (cIVF) in women aged 40 years or more and unexplained infertility. A cohort of 685 women undergoing either autologous conventional IVF or ICSI was retrospectively analyzed. The effects of conventional IVF or ICSI procedure on cumulative pregnancy and live birth rates were evaluated in univariate and in multivariable analysis. In order to reduce potential differences between women undergoing either IVF or ICSI and to obtain unbiased estimation of the treatment effect, propensity score was estimated. ICSI was performed in 307 couples (ICSI group), whereas cIVF was performed in 297 couples (cIVF group), resulting in 45 and 43 live deliveries, respectively. No differences were observed in morphological embryo quality, in the number of cleavage stage embryos, in the number of transferred embryos, and in the number of vitrified embryos. As for the clinical outcome, no differences were observed in pregnancy rate, cumulative pregnancy rate, live birth rate, cumulative live birth rate, and abortion rate. The present results suggest that ICSI is not associated with increased likelihood of a live birth for unexplained, non-male factor infertility, in women aged 40 years or more. |
topic |
in vitro fertilization icsi ivf non-male factor infertility cumulative live birth rates |
url |
https://www.mdpi.com/2077-0383/8/10/1694 |
work_keys_str_mv |
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