Antifibrotic Effect of a Novel Selective 11β-HSD2 Inhibitor (WZ51) in a rat Model of Myocardial Fibrosis

Antifibrotic Effect of a Novel Selective 11β-HSD2 Inhibitor (WZ51) in a rat Model of Myocardial Fibrosis

Myocardial fibrosis (MF) is one of the leading causes of end-stage heart disease. Many studies have confirmed that inflammation caused by aldosterone may play an important role in the process of MF. A selective 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) enzyme inhibitor can reduce the inacti...

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Bibliographic Details
Main Authors: Fei Zhuang, Qin Ge, Jianchang Qian, Zhe Wang, Yaoyao Dong, Mengchun Chen, Xiaodan Zhang, Wei Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
WZ51
myocardial fibrosis
11β-HSD2
aldosterone
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.629818/full

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