Association of Tumor Necrosis Factor Alpha 308 G/A Polymorphism with Asthma in Pakistani Population

• Main Authors: Nusrat Saba, Osman Yusuf, Sadia Rehman, Saeeda Munir, Naghman Bashir, Atika Mansoor, Ghazala Raja-Kaukab
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2015-10-01
• Series: Iranian Journal of Allergy, Asthma and Immunology
• Subjects: Asthma; Pakistani population; TNF alpha 308
• Online Access: https://ijaai.tums.ac.ir/index.php/ijaai/article/view/569

Asthma is a chronic inflammatory and remodeling disorder of the airways, in which many cells, cellular elements, and cytokines play important roles. The role of tumor necrosis factor- α (TNF-α) in asthma is unclear in Pakistani population. The aim of this study was to assess the relationship between TNF-α -308 polymorphism and asthma.Polymorphism of TNF-α (G-308-A locus; rs 1800629) in 329 asthmatic patients and 151 healthy  controls  was  evaluated.  DNA  was  prepared  from  blood  samples  of  cases  and controls. Samples were genotyped for TNF-α 308 G/A polymorphism.There was no significant difference in the frequency of GG (OR 1.049 with 95% CI 0.68-1.63) and GA (OR 0.987 with 95% CI 0.64-1.53) genotypes of TNF-α-308. The AA genotype was absent in cases and only one AA genotype was observed in the controls.The genetic polymorphism of TNF-α does not seem to be associated with asthma in Pakistani population.