Action of Trypanosoma rangeli in infections with virulent Trypanosoma cruzi populations

• Main Authors: MT Paláu, AJ Mejía, U Vergara, CA Zúñiga
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 2003-06-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: Trypanosoma cruzi; Trypanosoma rangeli; protective effect; Chagas disease; parasitemia level
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000400022

In experimental murine infections with Trypanosoma rangeli it has been observed development immune response to Trypanosoma cruzi. The aim of the present work was to analyze the result of antigenic stimuli and the protective effect with T. rangeli in T. cruzi infections. Mice groups immunized with metacyclic trypomastigotes of T. rangeli (Choachí-2V strain), derived from haemolymph and salivary gland and reinfected with T. cruzi virulent populations (Tulahuen strain, SA strain and Dm28c clone) from infected in vitro cells, showed decrease severity of disease outcomes, low parasitemia levels and 100% survival of all mice immunized, in comparison with groups infected only with T. cruzi populations, which demonstrated tissue affection, high parasitemia levels and the death of all animals. The above mentioned data contribute to understand the biological behaviour of T. cruzi and T. rangeli and their interaction with vertebrate host.