Comparative cardiovascular physiology and pathology in selected lineages of minipigs
The minipig has been increasingly recognized as a valid alternative to canines and nonhuman primates in regulatory toxicity. This article presents the results of cardiovascular assessments in the Yucatan, Hanford, Sinclair, and Göttingen minipigs conducted during nonclinical investigations and contr...
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doaj-9ccdc31b0e5e4b088b60d092b8a3a1b92020-11-25T03:30:57ZengSAGE PublishingToxicology Research and Application2397-84732017-03-01110.1177/2397847317696367Comparative cardiovascular physiology and pathology in selected lineages of minipigsAlain Stricker-Krongrad0Catherine Shoemake1Derek Brocksmith2Jason Liu3Robert Hamlin4Guy Bouchard5 Sinclair Research Center, Columbia, MO, USA Sinclair Research Center, Columbia, MO, USA Sinclair BioResources, Columbia, MO, USA Sinclair Research Center, Columbia, MO, USA The Ohio State University, Columbus, OH, USA Sinclair Research Center, Columbia, MO, USAThe minipig has been increasingly recognized as a valid alternative to canines and nonhuman primates in regulatory toxicity. This article presents the results of cardiovascular assessments in the Yucatan, Hanford, Sinclair, and Göttingen minipigs conducted during nonclinical investigations and control toxicity testing. Cardiac electrophysiology was obtained using clinical electrocardiogram and surgical monitor units. Peripheral vessel diameter, velocity, and flow were obtained by Doppler ultrasonography, and cardiac vessel diameter was obtained postmortem. Anatomic parameters were obtained at necropsy. Histopathology assessments were conducted on heart, blood vessels, and kidneys. Collected data were compared to published cardiovascular measurements of adult humans to illustrate similarities and differences. Each lineage of minipigs was found to have specific anatomic and physiologic characteristics that may accurately reflect response of human cardiovascular systems in clinical investigations and toxicity testing. In conclusion, the interspecies similarities between the cardiovascular systems make these lineages of minipigs suitable as models for the human counterpart. In addition, these reported differences between lineages will aid investigators in selecting a relevant lineage of minipigs if specific cardiovascular parameters are required during drug safety evaluation.https://doi.org/10.1177/2397847317696367 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alain Stricker-Krongrad Catherine Shoemake Derek Brocksmith Jason Liu Robert Hamlin Guy Bouchard |
spellingShingle |
Alain Stricker-Krongrad Catherine Shoemake Derek Brocksmith Jason Liu Robert Hamlin Guy Bouchard Comparative cardiovascular physiology and pathology in selected lineages of minipigs Toxicology Research and Application |
author_facet |
Alain Stricker-Krongrad Catherine Shoemake Derek Brocksmith Jason Liu Robert Hamlin Guy Bouchard |
author_sort |
Alain Stricker-Krongrad |
title |
Comparative cardiovascular physiology and pathology in selected lineages of minipigs |
title_short |
Comparative cardiovascular physiology and pathology in selected lineages of minipigs |
title_full |
Comparative cardiovascular physiology and pathology in selected lineages of minipigs |
title_fullStr |
Comparative cardiovascular physiology and pathology in selected lineages of minipigs |
title_full_unstemmed |
Comparative cardiovascular physiology and pathology in selected lineages of minipigs |
title_sort |
comparative cardiovascular physiology and pathology in selected lineages of minipigs |
publisher |
SAGE Publishing |
series |
Toxicology Research and Application |
issn |
2397-8473 |
publishDate |
2017-03-01 |
description |
The minipig has been increasingly recognized as a valid alternative to canines and nonhuman primates in regulatory toxicity. This article presents the results of cardiovascular assessments in the Yucatan, Hanford, Sinclair, and Göttingen minipigs conducted during nonclinical investigations and control toxicity testing. Cardiac electrophysiology was obtained using clinical electrocardiogram and surgical monitor units. Peripheral vessel diameter, velocity, and flow were obtained by Doppler ultrasonography, and cardiac vessel diameter was obtained postmortem. Anatomic parameters were obtained at necropsy. Histopathology assessments were conducted on heart, blood vessels, and kidneys. Collected data were compared to published cardiovascular measurements of adult humans to illustrate similarities and differences. Each lineage of minipigs was found to have specific anatomic and physiologic characteristics that may accurately reflect response of human cardiovascular systems in clinical investigations and toxicity testing. In conclusion, the interspecies similarities between the cardiovascular systems make these lineages of minipigs suitable as models for the human counterpart. In addition, these reported differences between lineages will aid investigators in selecting a relevant lineage of minipigs if specific cardiovascular parameters are required during drug safety evaluation. |
url |
https://doi.org/10.1177/2397847317696367 |
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