Retroviral activation of the mir-106a microRNA cistron in T lymphoma

Retroviral activation of the mir-106a microRNA cistron in T lymphoma

<p>Abstract</p> <p>Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstr...

Full description

Bibliographic Details
Main Authors: Bartha Gabor, Channa Namitha, Li Lauri, Wang Bruce B, Lum Amy M, Wabl Matthias
Format: Article
Language:English
Published: BMC 2007-01-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/4/1/5
id doaj-9ccead18860241a9934785835057c96c
record_format Article
spelling doaj-9ccead18860241a9934785835057c96c2020-11-24T21:23:41ZengBMCRetrovirology1742-46902007-01-0141510.1186/1742-4690-4-5Retroviral activation of the mir-106a microRNA cistron in T lymphomaBartha GaborChanna NamithaLi LauriWang Bruce BLum Amy MWabl Matthias<p>Abstract</p> <p>Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron. In tumors containing an integration, the primary transcript encoding the mir-106a cistron was overexpressed five to 20-fold compared with that of control tumors; concomitantly, the mature mir-106a and mir-363 microRNAs were highly overexpressed as well. These findings suggest the mir-106a cistron plays an important role in T cell tumorigenesis.</p> http://www.retrovirology.com/content/4/1/5
collection DOAJ
language English
format Article
sources DOAJ
author Bartha Gabor
Channa Namitha
Li Lauri
Wang Bruce B
Lum Amy M
Wabl Matthias
spellingShingle Bartha Gabor
Channa Namitha
Li Lauri
Wang Bruce B
Lum Amy M
Wabl Matthias
Retroviral activation of the mir-106a microRNA cistron in T lymphoma
Retrovirology
author_facet Bartha Gabor
Channa Namitha
Li Lauri
Wang Bruce B
Lum Amy M
Wabl Matthias
author_sort Bartha Gabor
title Retroviral activation of the mir-106a microRNA cistron in T lymphoma
title_short Retroviral activation of the mir-106a microRNA cistron in T lymphoma
title_full Retroviral activation of the mir-106a microRNA cistron in T lymphoma
title_fullStr Retroviral activation of the mir-106a microRNA cistron in T lymphoma
title_full_unstemmed Retroviral activation of the mir-106a microRNA cistron in T lymphoma
title_sort retroviral activation of the mir-106a microrna cistron in t lymphoma
publisher BMC
series Retrovirology
issn 1742-4690
publishDate 2007-01-01
description <p>Abstract</p> <p>Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron. In tumors containing an integration, the primary transcript encoding the mir-106a cistron was overexpressed five to 20-fold compared with that of control tumors; concomitantly, the mature mir-106a and mir-363 microRNAs were highly overexpressed as well. These findings suggest the mir-106a cistron plays an important role in T cell tumorigenesis.</p>
url http://www.retrovirology.com/content/4/1/5
work_keys_str_mv AT barthagabor retroviralactivationofthemir106amicrornacistronintlymphoma
AT channanamitha retroviralactivationofthemir106amicrornacistronintlymphoma
AT lilauri retroviralactivationofthemir106amicrornacistronintlymphoma
AT wangbruceb retroviralactivationofthemir106amicrornacistronintlymphoma
AT lumamym retroviralactivationofthemir106amicrornacistronintlymphoma
AT wablmatthias retroviralactivationofthemir106amicrornacistronintlymphoma
_version_ 1725991665063165952

Similar Items