Protective Effects of Valproic Acid, a Histone Deacetylase Inhibitor, against Hyperoxic Lung Injury in a Neonatal Rat Model.

Protective Effects of Valproic Acid, a Histone Deacetylase Inhibitor, against Hyperoxic Lung Injury in a Neonatal Rat Model.

Histone acetylation and deacetylation may play a role in the pathogenesis of inflammatory lung diseases. We evaluated the preventive effect of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, on neonatal hyperoxic lung injury.Forty newborn rat pups were randomized in normoxia, normoxia+V...

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Bibliographic Details
Main Authors: Merih Cetinkaya, Mehmet Cansev, Ferhat Cekmez, Cuneyt Tayman, Fuat Emre Canpolat, Ilker Mustafa Kafa, Esra Orenlili Yaylagul, Boris W Kramer, Serdar Umit Sarici
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4418724?pdf=render

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http://europepmc.org/articles/PMC4418724?pdf=render

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