Synthesis, characterization, in vitro cytotoxicity, and apoptosis-inducing properties of ruthenium(II) complexes.
Two new Ru(II) complexes, [Ru(bpy)2(FAMP)](ClO4)2 1 and 2, are synthesized and characterized by elemental analysis, electrospray mass spectrometry, and 1H nuclear magnetic resonance. The in vitro cytotoxicities and apoptosis-inducing properties of these complexes are extensively studied. Complexes 1...
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doaj-9cd1846de6a84dbfba3019fa5dd90f1f2020-11-25T00:07:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9608210.1371/journal.pone.0096082Synthesis, characterization, in vitro cytotoxicity, and apoptosis-inducing properties of ruthenium(II) complexes.Li XuNan-Jing ZhongYang-Yin XieHong-Liang HuangGuang-Bin JiangYun-Jun LiuTwo new Ru(II) complexes, [Ru(bpy)2(FAMP)](ClO4)2 1 and 2, are synthesized and characterized by elemental analysis, electrospray mass spectrometry, and 1H nuclear magnetic resonance. The in vitro cytotoxicities and apoptosis-inducing properties of these complexes are extensively studied. Complexes 1 and 2 exhibit potent antiproliferative activities against a panel of human cancer cell lines. The cell cycle analysis shows that complexes 1 and 2 exhibit effective cell growth inhibition by triggering G0/G1 phase arrest and inducing apoptosis by mitochondrial dysfunction. The in vitro DNA binding properties of the two complexes are investigated by different spectrophotometric methods and viscosity measurements.http://europepmc.org/articles/PMC4013043?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li Xu Nan-Jing Zhong Yang-Yin Xie Hong-Liang Huang Guang-Bin Jiang Yun-Jun Liu |
spellingShingle |
Li Xu Nan-Jing Zhong Yang-Yin Xie Hong-Liang Huang Guang-Bin Jiang Yun-Jun Liu Synthesis, characterization, in vitro cytotoxicity, and apoptosis-inducing properties of ruthenium(II) complexes. PLoS ONE |
author_facet |
Li Xu Nan-Jing Zhong Yang-Yin Xie Hong-Liang Huang Guang-Bin Jiang Yun-Jun Liu |
author_sort |
Li Xu |
title |
Synthesis, characterization, in vitro cytotoxicity, and apoptosis-inducing properties of ruthenium(II) complexes. |
title_short |
Synthesis, characterization, in vitro cytotoxicity, and apoptosis-inducing properties of ruthenium(II) complexes. |
title_full |
Synthesis, characterization, in vitro cytotoxicity, and apoptosis-inducing properties of ruthenium(II) complexes. |
title_fullStr |
Synthesis, characterization, in vitro cytotoxicity, and apoptosis-inducing properties of ruthenium(II) complexes. |
title_full_unstemmed |
Synthesis, characterization, in vitro cytotoxicity, and apoptosis-inducing properties of ruthenium(II) complexes. |
title_sort |
synthesis, characterization, in vitro cytotoxicity, and apoptosis-inducing properties of ruthenium(ii) complexes. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
Two new Ru(II) complexes, [Ru(bpy)2(FAMP)](ClO4)2 1 and 2, are synthesized and characterized by elemental analysis, electrospray mass spectrometry, and 1H nuclear magnetic resonance. The in vitro cytotoxicities and apoptosis-inducing properties of these complexes are extensively studied. Complexes 1 and 2 exhibit potent antiproliferative activities against a panel of human cancer cell lines. The cell cycle analysis shows that complexes 1 and 2 exhibit effective cell growth inhibition by triggering G0/G1 phase arrest and inducing apoptosis by mitochondrial dysfunction. The in vitro DNA binding properties of the two complexes are investigated by different spectrophotometric methods and viscosity measurements. |
url |
http://europepmc.org/articles/PMC4013043?pdf=render |
work_keys_str_mv |
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